Peptides and peptidomimetics having immune-modulating, anti-inflammatory, and anti-viral activity
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakumi Kawabe, Hidetaka Kobayashi
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Abstract
The invention provides compounds having immune-modulating and/or anti-inflammatory and/or anti-viral activity, wherein compounds of the invention include peptides and peptidomimetics. The invention further provides methods of using immune-modulating and/or anti-inflammatory and/or anti-viral compounds of the invention. In particular, the invention provides methods for treating a disease related to an immune disorder or inflammation or viral infection by administering an amount of a G2-checkpoint-abrogating peptide or peptidomimetic sufficient to inhibit the disease.
Claims10
A method of treating a disease selected from the group consisting of inflammation and arthritis by administering to a subject in need thereof an effective amount of a G2-checkpoint-abrogating peptide or peptidomimetic comprising the structure selected from the group consisting of CBP500 (SEQ ID NO:
- 124), CBP501 (SEQ ID NO:80), CBP504 (SEQ ID NO:
- 127), CBP505 (SEQ ID NO:
- 128), CBP506 (SEQ ID NO:
- 129), CBP510 (SEQ ID NO:93), CBP511 (SEQ ID NO:94), CBP512 (SEQ ID NO:95), and CBP603 (SEQ ID NO:89).
Dependencies are inferred from the claim text.