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AssigneeNew York University
InventorsBlas Frangione, Thomas Wisniewski, Einar M. Sigurdsson
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The present invention relates to immunogenic but non-depositing-forming polypeptides or peptides homologous to amyloid β, prion, amylin or α-synuclein which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid β peptides and amyloid deposits, to prion protein and prion deposits, to amylin and amylin deposits, to α-synuclein and deposits containing α-synuclein, or to polyglutamine repeats and deposits of proteins containing polyglutamine repeats. Described are also antibodies directed against such peptides, their generation, and their use in methods of passive immunization to such peptides and deposits.
An isolated polypeptide consisting of SEQ ID NO:55 in which two or more of the following sets, (i) residues 37 and 40, (ii) residues 48, 49, and 52, and (iii) residues 70, 71, and 74, are substituted with all Glu, all Asp, all Pro, all Lys, all Gly, or all Ser residues.
An isolated peptide consisting of a 30 to 36 residue segment, wherein the peptide is residues 1-30 to 1-36 of SEQ ID NO:
An isolated peptide consisting of a 30 to 66 residue segment, wherein the peptide is residues 75-140 to 111-140 of SEQ ID NO:
Dependencies are inferred from the claim text.