Human parathyroid hormone modifications, preparation and use
AssigneeThe General Hospital Corporation
InventorsF. Richard Bringhurst, Hisashi Takasu, Thomas J. Gardella, John T. Potts, Jr.
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Abstract
The present invention is related to synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28). Some of the peptides of the invention are at least 90% identical to a peptide consisting essentially of the amino acid sequence X01ValSerGluIleGlnLeuMetHis AsnLeuGlyLysHisLeuAsnSer MetX02ArgValGluTrpLeuArgLysLysLeu (SEQ ID NO:1), wherein X01 is Ser, Ala or Gly; and X02 is Glu or Arg.
Claims15
A method for treating a mammalian subject having a condition characterized by a decrease in bone mass, said method comprising administering to said subject an effective bone mass-increasing amount of a biologically active peptide consisting essentially of the formula:
- (a) X01ValSerGluIleGlnLeuMetHisAsnLeuGly LysHisLeuAsnSerMetX02ArgValGluTrpLeuArgLysLysLeu (SEQ ID NO:1);
- (b) fragments thereof containing amino acids 1-24, 1-25, 1-26, or 1-27;
- (c) pharmaceutically acceptable salts thereof;
- or
- (d) N- or C-terminal chemical derivatives thereof;
- wherein:
- X01 is Ser, Ala or Gly;
- and
- X02 is Glu or Arg,
- provided that said peptide is not hPTH(1-26)NH2, hPTH(1-27)NH2 or hPTH(1-28)NH2;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.