Analytical test element and method for blood analyses
AssigneeRoche Diagnostics Operations, Inc.
InventorsSiegfried Noetzel, Jean-Philippe Bogardi, Dieter Mangold
Life of this patent
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Abstract
An analytical test element for blood analyses is provided having at least a substrate body having a channel structure for the flow transport of a blood sample from an application site to at least one analytical site. The channel structure has a dilution channel that can be loaded with the blood sample and is provided with a separation component for retaining corpuscular blood components and has a sample channel which conveys a blood sample aliquot to be diluted and joins the dilution channel at a mixing site.
Claims19
An analytical test element comprising:
- an application site, a microfluidic channel structure in fluid communication with said application site, and at least one analytical site in fluid communication with said microfluidic channel structure, wherein the channel structure comprises a dilution channel for receiving a first portion of a blood sample applied to the application site which comprises separation means for retaining corpuscular blood components of said first portion, and a sample channel for receiving a second portion of the blood sample applied to the application site which conveys the second portion to a mixing site located at a point where the sample channel joins the dilution channel downstream of the separation means in order to dilute the second portion of the blood sample.
A method for carrying out blood analyses comprising providing an analytical test element comprising an application site, a microfluidic channel structure in fluid communication with said application site, and at least one analytical site in fluid communication with said microfluidic channel structure, applying a blood sample to be analyzed to said application site, moving said blood sample via said microfluidic channel structure from said application site to said at least one analytical site, obtaining liquid components from a first portion of the blood sample applied to the application site by passing the first portion through a dilution channel of the channel structure comprising separation means for retaining corpuscular blood components, and adding said liquid components to a second portion of the blood sample applied to the application site and conveyed through a sample channel of the channel structure, wherein the liquid components are added to the second portion of the blood sample at a mixing site located at a point where the sample channel joins the dilution channel downstream of the separation means.
Dependencies are inferred from the claim text.