Method for assessing behavioral predisposition
AssigneeWisconsin Alumni Research Foundation
InventorsAvshalom Caspi, Terrie E. Moffitt
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Abstract
The present invention relates to diagnostic methods for assessing predisposition of a subject to a mental disorder phenotype having an association with an at-risk allele of a brain-functional gene having a plurality of alleles, the association being conditioned by a pathogenic environmental risk factor status condition. Additionally, the invention relates to methods for discovering a conditional association between a mental disorder phenotype and an at-risk allele of a brain-functional gene having a plurality of alleles, the association being conditioned by a pathogenic environmental risk factor status condition.
Claims5
A method for assessing predisposition to a mental disorder phenotype selected from the group consisting of a conduct disorder, violent behavior and antisocial behavior in a human subject who has experienced childhood maltreatment, the method comprising the steps of:
- determining whether the subject carries a two- or three-repeat allele of a variable number tandem repeat polymorphism within a gene encoding human monoamine oxidase A enzyme, wherein a locus of the gene is amplified by SEQ ID NO:1 and SEQ ID NO:2;
- and
- concluding that the subject is predisposed to the phenotype if the subject carries the two- or three-repeat allele.
Dependencies are inferred from the claim text.