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US 7,479,373 B2Granted
Method for identifying compounds modulating taste transduction
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Health and Human Services
InventorsCharles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
Claims14
A method for identifying a compound that modulates taste signaling in taste cells, the method comprising the steps of:
- (i) contacting the compound with a taste transduction G-protein coupled receptor polypeptide, wherein the polypeptide is expressed in a taste cell and binds a bitter tastant, the polypeptide comprising greater than about 95% amino acid sequence identity to SEQ ID NO:41;
- and
- (ii) determining a functional effect of the compound upon the polypeptide, thereby identifying a compound that modulates taste signaling in taste cells.
Dependencies are inferred from the claim text.