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AssigneeCenix BioScience GmbH
InventorsChristophe Echeverri, Anthony Hyman, Pierre Gönczy, Birte Sönnichsen, Steven Jones, Andrew Walsh, Liisa Koski
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The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
A method for the identification and characterization of drugs that inhibit or activate spindle formation or microtubule function during cell division, wherein the method comprises using a nucleic acid molecule in a screening assay for the identification of said drug, and performing a functional analysis for the spindle formation or microtubule function during cell division, wherein the nucleic acid molecule comprises
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