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US 7,479,290 B2Granted
Solvent extraction process
AssigneeGlycomed Sciences Limited
InventorChris Lawson
Life of this patent
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Abstract
The present invention relates to an improved extraction process for an alkaloid glycoside extract from the species Solanum. In this process, a ground, dried plant tissue of the species Solanum is subjected to alcohol extraction using methanol, the extract is dried and dissolved in a weak volatile acid and centrifuged, the supernatant is precipitated using a volatile base, and the precipitate is thoroughly washed and dried. Extracts having high purity, and products made by the process are also provided.
Claims9
A process for the isolation of an extract of solasonine and solamargine comprising the following steps:
- a) ground, dried plant tissue of a Solanum species is subjected to alcohol extraction using methanol;
- b) the extract obtained is dried and dissolved in a weak volatile acid and centrifuged to provide a supernatant;
- c) the supernatant is precipitated using a volatile base, thereby providing a precipitate;
- d) the precipitate is washed and dried;
- and
- e) the precipitate as obtained in step d is subjected to silica gel chromatography to provide an extract comprising 30-50% of solasonine and 40-60% of solamargine, the extract comprising a combination of solasonine and solamargine above 90%.
3 more elements
Dependencies are inferred from the claim text.