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US 7,479,285 B1Granted
Methods of modulating an immune response using immunostimulatory sequences and compositions for use therein
AssigneeDynavax Technologies Corporation
InventorsGary Van Nest, Stephen Tuck, Joseph Eiden, Jr.
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Abstract
The invention provides methods of modulating an immune response to a second antigen which entail administration of a first antigen and an immunostimulatory polynucleotide. Modulation of the immune response is generally manifested as stimulation of a Th1 response.
Claims27
A method of modulating an immune response to a second antigen in an individual, comprising co-administering to the individual
- (i) a complex comprising an immunomodulatory polynucleotide covalently conjugated to a first antigen and
- (ii) a second antigen
- wherein the polynucleotide comprises an immunostimulatory sequence (ISS), wherein the ISS comprises the sequence 5′-cytosine, guanine-3′, wherein the complex and the second antigen are administered at the same site in the individual and wherein the complex is administered in an amount sufficient to modulate an immune response in the individual to the second antigen.
The method of 10, wherein interferon gamma production is stimulated.
A composition comprising
- (i) a complex comprising an immunomodulatory polynucleotide covalently conjugated to a first antigen and
- (ii) a second antigen,
- wherein the polynucleotide comprises an immunostimulatory sequence (ISS), wherein the ISS comprises the sequence 5′-cytosine, guanine-3′, and wherein the first antigen is a viral conserved polypeptide and the second antigen is a viral variable polypeptide.
A composition comprising
- (i) a complex comprising an immunomodulatory polynucleotide covalently conjugated to a first antigen and
- (ii) a second antigen,
- wherein the polynucleotide comprises an immunostimulatory sequence (ISS), wherein the ISS comprises the sequence 5′-cytosine, guanine-3′, and wherein the first antigen is an allergen.
Dependencies are inferred from the claim text.