Biomarker generator system
AssigneeAdvanced Biomarker Technologies, LLC
InventorRonald Nutt
Life of this patent
Estimating the term…
Abstract
A biomarker generator system for producing approximately one (1) unit dose of a biomarker. The biomarker generator system includes a small, low-power particle accelerator (“micro-accelerator”) and a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip. The micro-accelerator is provided for producing approximately one (1) unit dose of a radioactive substance, such as a substance that emits positrons. The radiochemical synthesis subsystem is provided for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a biomarker.
Claims32
A system for producing a radiochemical, said system comprising:
- a particle accelerator for generating a beam of charged particles having a maximum beam power of less than, or equal to, approximately fifty (50) watts, the beam consisting essentially of particles having a minimum energy greater than, or equal to, five (5) MeV, and for directing the beam of charged particles along a path;
- a target positioned in the path of the beam of charged particles, said target serving to receive a target substance having a composition selected for producing a radioactive substance during interaction with the beam of charged particles;
- and
- a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip, said radiochemical synthesis subsystem for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the radiochemical.
A system for producing a radiochemical, said system comprising:
- a cyclotron for generating a beam of charged particles having a maximum beam power of less than, or equal to, approximately fifty (50) watts, a the beam consisting essentially of particles having a minimum energy greater than, or equal to, five (5) MeV , and for directing the beam of charged particles along a path;
- a target positioned in the path of the beam of charged particles, said target serving to receive a target substance having a composition selected for producing a radioactive substance during interaction with the beam of charged particles;
- and
- a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip, said radiochemical synthesis subsystem for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the radiochemical.
A system for producing a radiochemical, said system comprising:
- a particle accelerator for producing per run a radioactive substance having a maximum activity of less than, or equal to, approximately sixty (60) mCi;
- and
- a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip, said radiochemical synthesis subsystem for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the radiochemical.
A method for the producing approximately one (1) unit dose of a PET biomarker, said method comprising the steps of:
- (a) providing a particle accelerator for generating a beam of charged particles having a maximum beam power of less than, or equal to, approximately fifty (50) watts, the beam consisting essentially of particles having a minimum energy greater than, or equal to, five (5) MeV, said particle accelerator being incapable of generating a beam of charged particles having a beam power in excess of approximately fifty (50) watts;
- (b) generating a beam of charged particles using said particle accelerator;
- (c) bombarding a substance with the beam of charged particles such as to produce a radioactive substance;
- (d) providing a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip, said radiochemical synthesis subsystem for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a PET biomarker;
- (e) transferring the radioactive substance to said radiochemical synthesis subsystem;
- (f) transferring at least one reagent to said radiochemical synthesis subsystem;
- and
- (g) synthesizing the approximately one (1) unit dose of a PET biomarker, using said radiochemical synthesis subsystem.
Dependencies are inferred from the claim text.