Ion fragmentation by reaction with neutral particles
AssigneeBruker Daltonik GmbH
InventorsRoman Zubarev, Alexander Misharin, Oleg Silivra, Frank Kjeldsen
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Abstract
The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral particles, whereby, at least in the case of bombardment of analyte ions with helium atoms from an FAB generator, a new type of fragmentation occurs which strongly resembles fragmentation by electron capture (ECD). The reactions may be performed in magnetic ion traps (ion cyclotron resonance cells, ICR), in RF ion traps according to Wolfgang Paul, in RF ion guides, or in free beams of analyte ions or neutral particles.
Claims24
Method for the fragmentation of analyte ions, wherein the analyte ions are fragmented by reactions with electronically excited or radical neutral particles.
Mass spectrometer for the acquisition of fragment ion spectra of an analyte substance, comprising
- a) an ion storage or guiding device to store or guide the analyte ions, and
- b) a generator to generate a beam of electronically excited or radical neutral particles which can be injected into the ion storage or guiding device.
Dependencies are inferred from the claim text.