Chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV), process for their production and applications
AssigneeChimera Pharma S.L.U.
InventorsJose Francisco Rodriguez Aguirre, Jose Ruiz Caston, Irene Saugar Gomez, Ana Maria Ona Blanco, Juan Ramon Rodriguez Fernandez-Alba
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Abstract
The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2 protein or a “1-n” fragment of said IBDV pVP2, wherein “n” is an integer comprised between 441 and 501, bound to a region B consisting of a heterologous polypeptide comprising a polypeptide of interest, such as a polypeptide useful for prophylactic, therapeutic or diagnostic purposes.
Claims25
A fusion protein capable of forming a virus-like particle, comprising a region A, wherein said region A consists of a pVP2 protein of infectious bursal disease virus (IBDV), or a fragment thereof, wherein said fragment comprises residues 1-441 of said pVP2 protein, and a region B comprising a heterologous polypeptide, wherein said heterologous polypeptide is not a native IBDV polypeptide and said heterologous polypeptide is useful in vaccination, therapy or diagnosis, and wherein said region B is bound to a terminal region of said region A.
A fusion protein capable of forming a virus-like particle, comprising a region A, wherein said region A consists of a pVP2 protein or a 1-n fragment of the pVP2 protein of infectious bursal disease virus (IBDV), wherein “n” is an integer between 441 and 501, and a region B comprising a heterologous polypeptide, wherein said heterologous polypeptide is not a native IBDV polypeptide and said heterologous polypeptide is useful in vaccination, therapy or diagnosis, and wherein said region B is bound to a terminal region of said region A.
A fusion protein capable of forming a virus-like particle, comprising a region A, wherein said region A consists of a pVP2 protein of infectious bursal disease virus (IBDV), or a fragment thereof, wherein said fragment comprises up to 501 contiguous amino acid residues starting after amino acid one of said pVP2 protein, and a region B comprising a heterologous polypeptide, wherein said heterologous polypeptide is not a native IBDV polypeptide and said heterologous polypeptide is useful in vaccination, therapy or diagnosis, and wherein said region B is bound to a terminal region of said region A.
Dependencies are inferred from the claim text.