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US 7,470,245 B2Granted
Extracorporeal pathogen reduction system
AssigneeXEPMED, Inc.
InventorsHosheng Tu, Hun-Chi Lin, Yu-An Chang
Life of this patent
Estimating the term…
Abstract
The invention relates to an apparatus system and methods for treatment of virus-infected or pathogen-loaded human blood components separated from normal components comprising a separation apparatus and treatment apparatus system that inactivate pathogens in an extracorporeal blood system.
Claims17
A method of extracorporeally treating a patient with a pathogen burden comprising:
- (a) filtering the patient's blood through a blood filtration apparatus configured for separating a plasma constituent from the blood, wherein the blood filtration apparatus comprises a chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the first plate and the second plate, wherein the first plate is either essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;
- means for directing blood into the chamber gap;
- a non-rotational drive structure;
- said second plate comprising the filter membrane means for separating plasma constituent from the blood, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
- a collecting means;
- means for directing the plasma constituent passing through said filter membrane means to said collecting means;
- and means for directing from the chamber gap a remaining constituent of the blood out of the chamber;
- (b) passing the plasma constituent through a pathogen-reduction means for reducing the pathogen burden in the plasma constituent;
- (c) returning cellular components of the patient's blood back to said patient;
- and
- (d) returning the treated plasma back to said patient.
8 more elements
A method of treating a patient with acute infections, sepsis, acute enterovirus infection or fulminant hepatitis comprising:
- (a) filtering the patient's blood though a blood filtration apparatus configured for separating a plasma constituent from the blood, wherein the blood filtration apparatus comprises a chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the first plate and the second plate, wherein the first plate is either essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;
- means for directing blood into the chamber gap;
- a non-rotational drive structure;
- said second plate comprising the filter membrane means for separating plasma constituent from the blood, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
- a collecting means;
- means for directing the plasma constituent passing through Mid filter membrane means to said collecting means;
- and means for directing from the chamber gap a remaining constituent of the blood out of the chamber;
- (b) passing the plasma constituent trough pathogen-reduction means for reducing the pathogen burden in the plasma constituent;
- and
- (c) returning cellular components and the cleaned plasma of the patient's blood back to said patient.
7 more elements
A method of treating a patient with an acute phase biodefense disease comprising:
- (a) filtering the patient's blood through a blood filtration apparatus configured for separating a plasma constituent from the blood, wherein the blood filtration apparatus comprises a chamber having a hollow interior enclosed by a first plate, a second plate, and a flexible seal element between the first plate and the second plate, wherein the first plate is either essentially parallel to or at an acute angle to the second plate so as to form a chamber gap for the hollow interior;
- means for directing blood into the chamber gap;
- a non-rotational drive structure;
- said second plate comprising the filter membrane means for separating plasma constituent from the blood, wherein the second plate is detachably coupled to said non-rotational drive structure that controls the second plate in an orbital motion in reference to a center axis of the first plate;
- a collecting means;
- means for directing the plasma constituent passing through said filter membrane means to said collecting means;
- and means for directing from the chamber gap a remaining constituent of the blood out of the chamber;
- (b) passing the plasma constituent through pathogen-reduction means for reducing the pathogen burden in the plasma constituent;
- and
- (c) returning cellular components and cleaned plasma of the patient's blood back to said patient.
7 more elements
Dependencies are inferred from the claim text.