# US 7,465,573 B2 · Molecular sequence of swine retrovirus and methods of use

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- Number: US 7,465,573 B2
- Document ID: US7465573B2
- Status: Granted
- Kind: B2
- Application number: 10/723,552
- Filed: 2003-11-26
- Published: 2004-09-23
- Granted: 2008-12-16
- Earliest claimed: 1995-12-14
- Assignees: The General Hospital Corporation
- Inventors: Jay A. Fishman
- Web page: https://patentgrep.com/patent/US7465573B2

## CPC

- C12N 15/8509: {for producing genetically modified animals, e.g. transgenic}
- C07K 14/005: from viruses
- C12N 7/00: Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00)
- C12N 15/86: Viral vectors
- C12Q 1/6888: for detection or identification of organisms
- C12Q 1/702: {for retroviruses}
- A01K 2217/05: Animals comprising random inserted nucleic acids (transgenic)
- A01K 2217/075: inducing loss of function, i.e. knock out
- A01K 2227/108: Swine
- A01K 2267/02: Animal zootechnically ameliorated
- A01K 2267/025: Animal producing cells or organs for transplantation
- C12N 2740/10021: Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C12N 2740/10022: New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C12N 2740/10043: viral genome or elements thereof as genetic vector
- C12N 2740/13021: Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C12N 2740/13022: New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C12N 2740/13043: viral genome or elements thereof as genetic vector
- C12N 2740/15043: viral genome or elements thereof as genetic vector
- C12Q 2600/156: Polymorphic or mutational markers
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A01K: ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS

## Abstract

Purified nucleic acid which can specifically hybridize with the sequence of swine retroviruses.

## Claims

### Claim 1

A purified polypeptide encoded by a nucleic acid molecule having at least 95% identity to a molecule selected from the group consisting of:
(a) nucleotides 585-2156 of SEQ ID NO:3 (gag);
(b) nucleotides 2307-5741 of SEQ ID NO:3 (pol); and
(c) nucleotides 5620-7533 of SEQ ID NO:3 (env).

### Claim 2

The purified polypeptide encoded by a nucleic acid moleclule selected fom the group consisting of:
(a) nucleotides 585-2156 of SEQ ID NO:3 (gag);
(b) nucleotides 2307-5741 of SEQ ID NO:3 (pol); and
(c) nucleotides 5620-7533 of SEQ ID NO:3 (env).

### Claim 3 (depends on 2)

The polypeptide of claim 2 that is encoded by nucleotides 585-2156 of SEQ ID NO:3.

### Claim 4 (depends on 2)

The polypeptide of claim 2 that is encoded by nucleotides 2307-5741 of SEQ ID NO:3.

### Claim 5 (depends on 2)

The polypeptide of claim 2 that is encoded by nucleotides 5620-7533 of SEQ ID NO:3.

### Claim 6

A purified polypeptide encoded by a sequence comprising at least 100 nucleotides of a nucleic acid molecule selected from the group consisting of:
(a) a nucleic acid molecule having at least 95% identity to nucleotides 585-2156 of SEQ ID NO:3(gag);
(b) a nucleic acid molecule having at least 95% identity to nucleotides 2307-574 1 of SEQ ID NO:3 (pol); or
(c) a nucleic acid molecule having at least 95% identity to nucleotides 5620-7533 of SEQ ID NO:3 (env).