# US 7,465,553 B2 · Psoriasin expression by breast epithelial cells

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- Number: US 7,465,553 B2
- Document ID: US7465553B2
- Status: Granted
- Kind: B2
- Application number: 10/331,200
- Filed: 2002-12-30
- Published: 2003-07-24
- Granted: 2008-12-16
- Earliest claimed: 2001-12-31
- Assignees: Dana-Farber Cancer Institute, Inc.
- Inventors: Kornelia Polyak; Charlotta Enerbäck
- Web page: https://patentgrep.com/patent/US7465553B2

## CPC

- G01N 33/57585: {involving compounds identifiable in body fluids}
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 35/00: Antineoplastic agents
- A61P 37/02: Immunomodulators
- G01N 33/57515: of the breast
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention features methods of diagnosing high grade ductal carcinoma in situ (DCIS) These methods involve measuring: (1) the level of HID-5 in a body fluid (e.g., blood or urine) of a subject suspected of having, or at risk of having, high grade DCIS; or (2) the level of HID-5 gene expression in breast tissue from a subject suspected of having, or at risk of having, high grade DCIS. The invention also embodies a method of inhibiting expression of HID-5 protein in DCIS cells and methods of treating a subject suspected of having, or at risk of having, high grade DCIS.

## Claims

### Claim 1

A method of diagnosis, the method comprising:
(a) identifying a subject suspected of having or at risk of having high-grade ductal carcinoma in situ (DCIS); and
(b) measuring the level of psoriasin in a sample of a body fluid, a lavage, or an aspirate from the subject,
wherein an elevated level of psoriasin in the sample, compared to a control level of psoriasin, is an indication that the subject has high grade DCIS.

### Claim 2 (depends on 1)

The method of claim 1, wherein the body fluid is blood.

### Claim 3 (depends on 1)

The method of claim 1, wherein the body fluid is urine.

### Claim 4 (depends on 1)

The method of claim 1, wherein the lavage is a breast duct lavage.

### Claim 5 (depends on 1)

The method of claim 1, wherein the aspirate is a nipple aspirate.