# US 7,465,460 B1 · Composition of low viscosity and method for treating skin

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- Number: US 7,465,460 B1
- Document ID: US7465460B1
- Status: Granted
- Kind: B1
- Application number: 10/995,501
- Filed: 2004-11-24
- Granted: 2008-12-16
- Earliest claimed: 1999-06-23
- Inventors: Dennis Gross
- Web page: https://patentgrep.com/patent/US7465460B1

## CPC

- A61K 8/0208: {Tissues; Wipes; Patches}
- A61K 8/19: containing inorganic ingredients
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups
- A61K 8/86: Polyethers
- A61P 17/00: Drugs for dermatological disorders
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
- A61K 2800/884: Sequential application
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A method for the topical treatment of skin aging and acne and the improvement of skin appearance is disclosed. Compositions for use in this method and a kit containing such compositions are also disclosed. In some of the embodiments of the invention, either one, or both, of the acid composition and neutralizing composition useful in the method for the topical treatment of skin aging and acne and the improvement of skin appearance are of low viscosity. The compositions and methods are effective but gentle enough suitable for daily home use by the consumer.

## Claims

### Claim 1

A method for treating skin, comprising the sequential steps of:
a) applying to the skin a first dermatological liquid composition comprising an effective amount of at least one acid, about 0.1% to about 10% of at least one surfactant/emulsifying agent and a cosmetically acceptable vehicle, wherein the pH of the first dermatological liquid composition is between about 2.5 and about 4; and thereafter
b) neutralizing the first dermatological liquid composition by applying to the skin a second dermatological liquid composition comprising at least one alkaline agent suitable for use in a skin care composition, about 0.1% to about 10% by weight of at least one surfactant/emulsifying agent and a cosmetically acceptable vehicle, wherein the pH of the second dermatological liquid composition ranges from greater than about 7 to about 12,
wherein each of the first dermatological liquid composition and the second dermatological liquid composition has a viscosity of about 1 cps to about 500 cps.

### Claim 2 (depends on 1)

The method of claim 1, wherein the pH of the second dermatological liquid composition is between about 7.1 and about 12.

### Claim 3 (depends on 2)

The method of claim 2, wherein the pH of the second dermatological liquid composition is between about 8 and about 8.5.

### Claim 4 (depends on 1)

The method of claim 1, wherein the amount of the at least one surfactant/emulsifying agent in the second dermatological liquid composition is from about 1% to about 5%.

### Claim 5 (depends on 4)

The method of claim 4, wherein the amount of the at least one surfactant/emulsifying agent in the second dermatological liquid composition is from about 2% to about 3%.

### Claim 6 (depends on 1)

The method of claim 1, wherein the at least one surfactant/emulsifying agent of the second dermatological liquid composition is selected from the group consisting of ceteareths, ceteths, cetyl alcohol, deceths, dodoxynols, glyceryl palmitate, glyceryl stearate, laneths, myreths, nonoxynols, octoxynols, oleths, PEG-castor oil, poloxamers, poloxamines, polysorbates, ammonium laureth sulfate, sodium laureth sulfate, and mixtures thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition comprises about 0.1% to about 5% of the at least one acid.

### Claim 8 (depends on 7)

The method of claim 7, wherein the first dermatological liquid composition comprises about 1% to about 3% of the at least one acid.

### Claim 9 (depends on 8)

The method of claim 8, wherein the first dermatological liquid composition comprises about 2% of the at least one acid.

### Claim 10 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition and the second dermatological liquid composition are each applied with use of a pad.

### Claim 11 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition and the second dermatological liquid composition are each applied with use of a cotton ball.

### Claim 12 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition and the second dermatological liquid composition are each applied with use of a cotton-tipped applicator.

### Claim 13 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition is applied by massaging into the skin.

### Claim 14 (depends on 1)

The method of claim 1, wherein the second dermatological liquid composition is applied by massaging into the skin.

### Claim 15 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition and the second dermatological liquid composition are each individually applied by massaging into the skin.

### Claim 16 (depends on 1)

The method of claim 1, wherein the at least one acid in the first dermatological liquid composition is at least one hydrophilic acid.

### Claim 17 (depends on 16)

The method of claim 16, wherein the at least one acid is selected from the group consisting of hydroxy carboxylic acids, keto acids and hydroxybenzoic acids.

### Claim 18 (depends on 17)

The method of claim 17, wherein the at least one acid is selected from the group consisting of alpha-hydroxy acids, salicylic acid and beta-hydroxy acids.

### Claim 19 (depends on 1)

The method of claim 1, wherein the at least one acid is selected from the group consisting of salicylic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, ascorbic acid, mandelic acid, azelaic acid, glyceric acid, tartronic acid, gluconic acid, benzylic acid, pyruvic acid, 2-hydroxybutyric acid, trichloroacetic acid, hydrochloric acid and phosphoric acid.

### Claim 20 (depends on 19)

The method of claim 19, wherein the at least one acid is selected from salicylic acid, lactic acid, glycolic acid and citric acid.

### Claim 21 (depends on 20)

The method of claim 20, wherein the at least one acid is a combination of salicylic acid, lactic acid and glycolic acid.

### Claim 22 (depends on 1)

The method of claim 1, wherein the at least one alkaline agent in the second dermatological liquid composition is selected from the group consisting of sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, ammonia and triethanolamine.

### Claim 23 (depends on 22)

The method of claim 22, wherein the at least one alkaline agent in the second dermatological liquid composition is selected from the group consisting of sodium bicarbonate, sodium carbonate, potassium bicarbonate and potassium carbonate.

### Claim 24 (depends on 23)

The method of claim 23, wherein the at least one alkaline agent in the second dermatological liquid composition is selected from sodium bicarbonate and sodium carbonate.

### Claim 25 (depends on 24)

The method of claim 24, wherein the at least one alkaline agent in the second dermatological liquid composition is sodium bicarbonate.

### Claim 26 (depends on 1)

A method for treating skin according to claim 1, wherein the pH of the first dermatological liquid composition is between about 3 and about 4.

### Claim 27 (depends on 26)

The method of claim 26, wherein the pH of the second dermatological liquid composition is between about 7.1 and about 12.

### Claim 28 (depends on 27)

The method of claim 27, wherein the pH of the second dermatological liquid composition is between about 8 and about 8.5.

### Claim 29 (depends on 26)

The method of claim 26, wherein the amount of the at least one surfactant/emulsifying agent in the second dermatological liquid composition is from about 1% to about 5%.

### Claim 30 (depends on 29)

The method of claim 29, wherein the amount of the at least one surfactant/emulsifying agent in the second dermatological liquid composition is from about 2% to about 3%.

### Claim 31 (depends on 1)

The method of claim 1, wherein the first dermatological liquid composition comprises the following ingredients:
weight percent
ingredients
from
to
chelating agent
0.01%
0.3%
witch hazel distillate
0.01%
20.0%
surfactant/emulsifying agent
0.01%
25.0%
salicylic acid
0.1%
5.0%
lactic acid
0.1%
20.0%
glycolic acid
0.1%
20.0%
ammonia, dissolved
0.0%
35.0%
preservative
0.01%
2.0%
acetone
0.0%
10.0%
alcohol
1.0%
50.0%
purified water
balance to 100%; and
to
the second dermatological liquid composition comprises the following ingredients:
weight percent
ingredients
from
to
sodium bicarbonate
0.1%
15.0%
silicone
0.0%
50.0%
green tea extract
0.0%
75.0%
phospholipids
0.0%
10.0%
vitamin E
0.0%
10.0%
vitamin A
0.0%
10.0%
ascorbyl palmitate
0.0%
10.0%
preservative
0.0%
6.0%
chelating agent
0.0%
2.0%
surfactant/emulsifying agent
0.1%
10.0%
water
balance to 100%.

### Claim 32 (depends on 31)

The method of claim 31, wherein the first dermatological liquid composition comprises the following ingredients:
ingredients
weight percent
Disodium EDTA
0.1%
Sodium Benzoate
0.2%
Witch Hazel Distillate
2.5%
Polysorbate-20
1.0%
Salicylic Acid
2.0%
Lactic Acid
2.0%
Glycolic Acid
15.0%
Ammonia, dissolved
6.0%
Imidazolidinyl Urea
0.2%
Acetone
5.0%
Ethanol
5.0%
Purified Water
balance to 100%.

### Claim 33 (depends on 31)

The method of claim 31, wherein the second dermatological liquid composition comprises the following ingredients:
ingredients
weight percent
sodium bicarbonate
3.0%
dimethicone copolyol
0.75%
green tea extract
0.2%
phospholipids
0.5%
vitamin E
0.5%
vitamin A
0.5%
ascorbyl palmitate
0.5%
phenoxyethanol
0.01%
methylparaben
0.01%
diazolidinyl urea
0.01%
tetrasodium EDTA
0.01%
octoxynol-9
2.0%
water
balance to 100%.

### Claim 34 (depends on 32)

The method of claim 32, wherein the second dermatological liquid composition comprises the following ingredients:
ingredients
weight percent
sodium bicarbonate
3.0%
dimethicone copolyol
0.75%
green tea extract
0.2%
phospholipids
0.5%
vitamin E
0.5%
vitamin A
0.5%
ascorbyl palmitate
0.5%
phenoxyethanol
0.01%
methylparaben
0.01%
diazolidinyl urea
0.01%
tetrasodium EDTA
0.01%
octoxynol-9
2.0%
water
balance to 100%.

### Claim 35 (depends on 1)

The method of claim 1, wherein the amount of the at least one surfactant/emulsifying agent in the first dermatological liquid composition is about 2% to about 6%.

### Claim 36 (depends on 35)

The method of claim 35, wherein the amount of the at least one surfactant/emulsifying agent in the first dermatological liquid composition is about 3% to about 5%.

### Claim 37 (depends on 1)

The method of claim 1, wherein each of the first dermatological liquid composition and the second dermatological liquid composition has a viscosity of about 1 cps to about 50 cps.

### Claim 38 (depends on 37)

The method of claim 37, wherein each of the first dermatological liquid composition and the second dermatological liquid composition has a viscosity of about 1 cps to about 20 cps.

### Claim 39 (depends on 1)

The method of claim 1, wherein each of the first dermatological liquid composition and the second dermatological liquid composition has a viscosity of about 5 cps to about 300 cps.

### Claim 40 (depends on 39)

The method of claim 39, wherein each of the first dermatological liquid composition and the second dermatological liquid composition has a viscosity of about 10 cps to about 200 cps.