# US 7,465,298 B2 · Methods and systems for delivering liquid substances to tissues surrounding body lumens

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 7,465,298 B2
- Document ID: US7465298B2
- Status: Granted
- Kind: B2
- Application number: 10/610,790
- Filed: 2003-06-30
- Published: 2004-01-15
- Granted: 2008-12-16
- Earliest claimed: 2002-06-28
- Assignees: Mercator MedSystems, Inc.
- Inventors: Kirk Patrick Seward; Lynn Barr; Judith Carol Wilber
- Web page: https://patentgrep.com/patent/US7465298B2

## CPC

- A61F 2/91: made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes
- A61F 2/915: with bands having a meander structure, adjacent bands being connected to each other
- A61F 2002/91533: {characterised by the phase between adjacent bands}
- A61F 2250/0068: the pharmaceutical product being in a reservoir
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Methods, systems, and apparatus for delivering drugs and other substances to extraluminal tissue surrounding a body lumen are described. Catheters are used to inject the drug or other substance intraluminally into tissue surrounding a stent or other luminal scaffold. The drug or other substance is injected in an amount sufficient to cause diffusion back through the tissue to the stent. An absorptive structure, reservoir, or the like, on the stent then absorbs excess drug as it passes from the luminal tissue. In this way, the stent is first loaded with drug. After time, as the stent becomes fully loaded and the tissue becomes depleted, drug will be begin to flow back from the stent into the surrounding luminal tissue.

## Claims

### Claim 1

A method for delivering a liquid substance to tissue surrounding a blood vessel, said method comprising:
injecting the substance into at least one location in the tissue by advancing an injection needle from a lumen of the blood vessel into the tissue; and
implanting a luminal scaffold at said location after the substance has been injected, wherein the luminal scaffold is adapted to imbibe the substance released from the tissue after injection and to release the imbibed substance back into the tissue over time.

### Claim 2 (depends on 1)

A method as in claim 1, wherein the substance is injected into the adventitia.

### Claim 3 (depends on 1)

A method as in claim 1, wherein the substance comprises a lipophilic agent selected from the group consisting of antineoplastic agents, antiproliferative agents, immunosuppressive agents, anti-inflammatory agents, macrolide antibiotics, antibiotics, antifungals, antivirals, antibodies, lipid lowering treatments, gene therapy agents, anti-sense drugs, metalloproteinase inhibitors, growth factor inhibitors, cell cycle inhibitors, angiogenesis drugs, anti-angiogenesis drugs, and radio-opaque contrast media.

### Claim 4 (depends on 1)

A method as in claim 1, wherein the scaffold comprises an expandable frame component having a surface which is at least partly covered by a liquid absorptive structure.

### Claim 5 (depends on 4)

A method as in claim 4, wherein the absorptive structure comprises a material selected from the group consisting of a hydrophilic polymer, a hydrophobic polymer, a porous ceramic, and a phosphorylcholine.

### Claim 6 (depends on 4)

A method as in claim 4, wherein the absorptive structure comprises a reservoir covered by a porous membrane.

### Claim 7 (depends on 1)

A method as in claim 1, wherein the blood vessel is a coronary artery.