# US 7,465,268 B2 · Methods for asymmetrical irradiation of a body cavity

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- Number: US 7,465,268 B2
- Document ID: US7465268B2
- Status: Granted
- Kind: B2
- Application number: 11/593,789
- Filed: 2006-11-06
- Published: 2007-07-19
- Granted: 2008-12-16
- Earliest claimed: 2005-11-18
- Assignees: SenoRx, Inc.
- Inventors: Paul Lubock; Michael L. Jones; Frank R. Louw
- Web page: https://patentgrep.com/patent/US7465268B2

## CPC

- A61N 5/1014: {Intracavitary radiation therapy}
- A61N 5/1002: {Intraluminal radiation therapy}
- A61N 5/1015: {Treatment of resected cavities created by surgery, e.g. lumpectomy}
- A61N 2005/1003: {having means for centering a radioactive source within the lumen, e.g. balloons}
- A61N 2005/1004: {having expandable radiation sources}
- A61N 2005/1005: {with asymmetrical radiation pattern}
- A61N 2005/1018: {with multiple channels for guiding radioactive sources}
- A61N 2005/1024: {Seeds}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

## Claims

### Claim 1

A method for treating tissue surrounding a body cavity of a patient, comprising:
a) providing a device having an elongated shaft, a distal shaft portion, a treatment location at the distal shaft portion, an expandable cavity filling member disposed about the distal shaft portion with an expanded configuration that at least partially fills the body cavity and at least one tubular member within the treatment location having a distal end coupled to the distal shaft portion, an extended configuration with an arcuate portion curving away from the distal shaft portion and spaced inwardly from the expandable cavity filling member in the extended configuration and a lumen extending within the tubular member having or configured to receive a radiation source;
b) inserting the device into the patient and advancing the device therein until the treatment location is deployed within the body cavity;
c) expanding the cavity filling member within the body cavity;
d) positioning at least one tubular member within the body cavity so that the arcuate portion of the tubular member is closer to a first portion of tissue surrounding the body cavity than a second portion of tissue surrounding the body cavity; and
e) providing a radiation source within the lumen of at least one tubular member closer to the first portion of tissue surrounding the body cavity to asymmetricalIy irradiate so that the first portion of tissue surrounding the body cavity receives a greater amount of radiation than the second portion of tissue surrounding the body cavity.

### Claim 2 (depends on 1)

The method of claim 1 wherein at least one of the tubular members is deflected to the extended configuration with an arcuate shape in order to position the radiation source within the inner lumen so that the radiation source within the lumen is closer to the first portion of tissue than the second portion of tissue.

### Claim 3 (depends on 1)

The method of claim 1 wherein the distal portion of the shaft is deflected by pulling a pull wire connected to the shaft distal to the treatment location.

### Claim 4 (depends on 1)

The method of claim 1 wherein the at least one tubular member is positioned within the body cavity by rotating the distal portion to place the radiation source within the lumen of the tubular member closer to the first tissue portion.

### Claim 5 (depends on 1)

The method of claim 1 including positioning a radiation shielding component between the radiation source and the second tissue portion to shield the second tissue portion from radiation emitted from the radiation source.