Peptides for diagnostic and therapeutic methods for celiac sprue
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsChaitan Khosla, Jiang Xia, Matthew John Siegel
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Abstract
Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
Claims7
A purified oligopeptide, wherein the oligopeptide comprises SEQ ID NO:33, LQLQPFPQPEKPYPQPELPY.
A purified oligopeptide, wherein the oligopeptide comprises SEQ ID NO:35, LQLQPFPQPEKPYPQPEKPY.
A purified oligopeptide comprising SEQ ID NO:33, LQLQPFPQPEKPYPQPELPY, or SEQ ID NO:35 LQLQPFPQPEKPYPQPEKPY wherein residues 11 and 18 are modified with cysteine substitutions.
A purified oligopeptide selected from the group consisting of SEQ ID NO:35, LQLQPFPQPEKPYPQPEKPY and SEQ ID NO:33, LQLQPFPQPEKPYPQPELPY.
Dependencies are inferred from the claim text.