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US 7,462,593 B2Granted
Compositions and methods for promoting angiogenesis
OwnerFrank Cuttitta, Alfredo Martinez +1inventors
InventorsFrank Cuttitta, Alfredo Martinez, William G. Stetler-Stevenson
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Abstract
The present disclosure concerns the use of peptides and compositions, such as pharmaceutical compositions, to influence angiogenesis. Particular methods are useful for promoting angiogenesis, while others are particularly useful for inhibiting angiogenesis.
Claims10
A method of inducing or promoting angiogenesis:
- (a) in a tissue, the method comprising:
- introducing into the tissue an effective amount of the peptide of SEQ ID NO:
- 4 or a variant or fragment thereof that has at least 95% sequence identity with SEQ ID NO:
- 4 and that retains angiogenic activity, thereby inducing angiogenesis in the tissue, or
- (b) in a target area in a subject where angiogenesis is desired, the method comprising:
- introducing into the target area a therapeutically effective amount of the peptide of SEQ ID NO:
- 4 or a variant or fragment thereof that has at least 95% sequence identity with SEQ ID NO:
- 4 and that retains angiogenic activity, thereby promoting angiogenesis in the target area in the subject.
5 more elements
Dependencies are inferred from the claim text.