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US 7,462,592 B2Granted
Compositions and methods for polynucleotide delivery
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsRonald N. Zuckermann, Nathalie Dubois-Stringfellow, Varavani Dwarki, Michael A. Innis, John E. Murphy, Fred E. Cohen, Tetsuo Uno
Life of this patent
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Abstract
This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
Claims13
A polycationic agent having the following formula:
- wherein
- n is an integer from 10 to 100;
- R1, R2, and R3 for each monomer,
- are independently selected from moieties having a molecular weight from 1 to 200 daltons;
- Ta and Tc are terminating groups;
- R1 is not hydrogen for at least one monomer;
- wherein said polycationic agent comprises at least 25% positively charged monomers, excluding the terminal groups, and
- wherein said polycationic agent exhibits a net positive electrical charge at a physiological pH.
5 more elements
Dependencies are inferred from the claim text.