Drug delivery particle
AssigneeBoston Scientific Scimed, Inc.
InventorsJanel L. Lanphere, Erin P. McKenna, Wendy Naimark, Marcia S. Buiser, Stephan P. Mangin
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Abstract
A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
Claims31
A drug delivery device comprising:
- a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size,
- wherein the second predominant pore size is from about 50% to about 70% of the first predominant pore size.
A method of manufacturing a drug delivery particle, the method comprising:
- generating drops comprising polyvinyl alcohol and alginate;
- forming the drops into particles;
- and
- combining the particles with a therapeutic agent,
- wherein each of the particles is a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size.
A method of delivering a substantially spherical particle to a patient, the method comprising administering to a patient the substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size.
A method of delivering a therapeutic agent to a patient, the method comprising:
- administering to a patient a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size;
- and
- releasing the therapeutic agent in the patient.
Dependencies are inferred from the claim text.