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US 7,460,914 B2Granted
Devices and methods to stimulate therapeutic angiogenesis for ischemia and heart failure
AssigneeCardiac Pacemakers, Inc.
InventorsEvgenia Mandrusov, Paul Consigny, Rodney W. Salo
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Abstract
A method for stimulating angiogenesis is provided that includes the use of an electrical output channel adapted to deliver a sub-threshold voltage, a lead that includes a proximal end adapted to be electrically connected to the electrical output channel and a distal end adapted to be placed in the blood conduit where the distal end of the lead is adapted to deliver a treatment agent that stimulates therapeutic angiogenesis, and at least one electrode on the distal end of the first lead.
Claims18
A method for stimulating angiogenesis, comprising:
- positioning a first electrode on an implantable first lead at a first intravascular location;
- connecting the first lead to an implantable first electrical output channel adapted to deliver a sub-threshold voltage such that the first electrode is electrically connected to the first electrical output channel, the sub-threshold voltage below a threshold voltage required to cause a local depolarization of cardiac myocyte cell membranes;
- activating the first electrical output channel to deliver the sub-threshold voltage through the first lead to the first electrode;
- and
- delivering a treatment agent adapted to stimulate therapeutic angiogenesis at the first intravascular location via an implantable cannula including a lumen configured to deliver a liquid or solid treatment agent to a distal end of the first lead, wherein the first lead includes at least a portion disposed within the lumen and has an outer diameter that is smaller than an inner diameter of the cannula to form an annular space suitable for flow of the liquid or solid treatment agent;
- wherein the first lead is adapted to deliver the sub-threshold voltage and one or more of pacing or defibrillation voltages to the first electrode.
3 more elements
A method for stimulating angiogenesis, comprising:
- delivering a sub-threshold voltage to a location in a blood vessel through an implantable lead having an electrode positioned in the blood vessel, wherein the lead is connected to an implantable electrical output channel adapted to deliver a sub-threshold voltage to the electrode, the sub-threshold voltage below a threshold voltage required to cause a local depolarization of cardiac myocyte cell membranes;
- and
- delivering a treatment agent adapted to stimulate therapeutic angiogenesis at the location via an implantable cannula including a lumen configured to deliver a liquid or solid treatment agent to a distal end of the lead, wherein the lead includes at least a portion disposed within the lumen and has an outer diameter that is smaller than an inner diameter of the cannula to form an annular space suitable for flow of the liquid or solid treatment agent;
- and
- wherein the lead is adapted to deliver the sub-threshold voltage and one or more of pacing or defibrillation voltages to the electrode.
2 more elements
Dependencies are inferred from the claim text.