MALDI/LDI source
AssigneeThermo Finnigan LLC
InventorViatcheslav V. Kovtoun
Life of this patent
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Abstract
A MALDI/LDI source includes an ion collection device, e.g., a skimmer, orifice, mass analyzer, ion transfer optics and/or ion guide, configured for use with a short focal length lens with a large aperture. In some embodiments, the ion collection device includes an outer edge that can be disposed approximately parallel to a beam envelope between a lens and a focal point positioned at a MALDI/LDI sample. This configuration of the outer edge allows the ion collection device to be placed in close proximity to the focal point. This placement results in favorable collection efficiencies of laser desorbed analyte from the MALDI/LDI sample.
Claims18
A system comprising:
- a sample support configured to support a sample on a first surface;
- a first beam focusing optics configured to direct a first radiation along a beam envelope to a focal point on the sample, and having a focal length of less than 20 millimeters, the first beam focusing optics being disposed approximately parallel to the first surface;
- and
- a first ion collection device configured to collect ions generated from the sample using the directed radiation, the first ion collection device having a first outer edge approximately parallel to the beam envelope along which the first radiation is directed by the first beam focusing optics, and being disposed less than 10 millimeters from the focal point.
Dependencies are inferred from the claim text.