Benzene derivatives and pharmaceutical use thereof

A benzene compound of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein R1 represents a cycloalkyl group substituted with at least one substituent selected from the group consisting of a halogen atom, an alkyl group, an alkoxycarbonyl group, a cyano group, an amino group, an alkylamino group, and a protected amino group;
• or
• a cycloalkenyl group substituted with at least one substituent selected from the group consisting of a halogen atom, an alkyl group, an alkoxycarbonyl group, a cyano group, an amino group, an alkylamino group, and a protected amino group;
• R2 represents hydrogen atom or an alkyl group;
• R3 to R10, which may be the same or different from each other, represent hydrogen atom, a halogen atom, hydroxyl group, mercapto group, nitro group, cyano group, trifluoromethyl group, an alkyl group, an alkoxyl group, an alkylthio group, an amino group which may be substituted with an alkyl group or an amino-protecting group, an acyloxy group, an acyl group, carboxyl group, an alkoxycarbonyl group or carbamoyl group;
• —Y represents a group of formula (II):
• wherein R11 represents hydrogen atom or an alkyl group;
• and
• R12 represents:
• an alkyl group which may have a substituent;
• a cycloalkyl group which may be substituted with at least one substituent selected from the group consisting of a halogen atom, an alkyl group, an alkoxycarbonyl group, a cyano group, an amino group, an alkylamino group, and a protected amino group, wherein said cycloalkyl group is one member selected from the group consisting of a cyclopropyl group, a cyclobutyl group, and a cyclopentyl group;
• a cycloalkenyl group which may be substituted with at least one substituent selected from the group consisting of a halogen atom, an alkyl group, an alkoxycarbonyl group, a cyano group, an amino group, an alkylamino group, and a protected amino group;
• an aryl group which may have a substituent;
• an aromatic heterocyclic group having one or more hetero atoms, which may have a substituent;
• or
• a saturated heterocyclic group having one or more hetero atoms, which may have a substituent;
• n represents an integer selected from among 0 to 6;
• and ——X—represents an interatomic bond, or any of —O—, —O—CHR17—, —CHR18—O—, —O—CO—, —CO—O—, —O—CS—, —CS—O—, —S—, —SO—, —SO2—, —S—CHR19—, —CHR20—S—, —S—CO—, —CO—S—, —S—CS—, —CS—S—, —SO2—NR21—, —NR22—SO2—, —NR23—, —NR24—CHR25—, —CHR26—NR27—, —CO—, —C(═NOR28)—, —C(═CHR29)—, —CO—CHR30—, —CHR31—CO—, —CO—NR32—, —NR33—CO—, —CR34R35—, —CHR36—CHR37—, and —CR38═CR39— wherein R17, R18, R19, R20, R21, R22, R25, R26, R29, R30, R31, R32, R33, R34, R38, and R39 each represent hydrogen atom or an alkyl group, R23, R24, R27 and R28 each represent hydrogen atom, an alkyl group or an acyl group, R36 and R37 each represent hydrogen atom, hydroxyl group or an alkyl group, and R35 represents hydrogen atom, hydroxyl group, mercapto group, cyano group, an alkyl group which may have a substituent, an alkoxyl group, an alkylthio group, an acyloxy group, an amino group which may be substituted with an alkyl group or an amino-protecting group, carboxyl group, an alkoxycarbonyl group or carbamoyl group.