Method of purifying epoxy compound
AssigneeSumitomo Chemical Company, Limited
InventorsTadashi Mizuno, Nobuhiro Arai, Erina Honda, Hideo Muraoka
Life of this patent
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Abstract
An epoxy compound of the formula (1): wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an optionally substituted aromatic group, can be purified by dissolving a crude product containing the epoxy compound (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of water and an organic solvent, which is capable of phase-separating from water, obtaining the organic layer by phase separation, washing with water and then subjecting to isolation of the epoxy compound (1) without decomposition.
Claims13
A method of purifying an epoxy compound of the formula (1):
- wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an aromatic group optionally substituted with one or more substituents selected from the group consisting of halogen atoms and trifluoromethyl group,
- which comprises dissolving a crude product containing the epoxy compound of the formula (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of water and an organic solvent, which is capable of phase-separating from water, obtaining the organic layer by phase separation, washing with water,concentrating and then subjecting to isolation of the epoxy compound of the formula (1) by distillation.
The method of purifying the epoxy compound of the formula (1)
- wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an aromatic group optionally substituted with one or more substituents selected from the group consisting of halogen atoms and trifluoromethyl group,
- which comprises dissolving a crude product containing the epoxy compound of the formula (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of acidic water and an organic solvent, which is capable of phase separating from water, obtaining the organic layer by phase separation, washing with water and then subjecting to isolation of the epoxy compound of the formula (1).
The method of purifying the epoxy compound of the formula (1):
- wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an aromatic group optionally substituted with one or more substituents selected from the group consisting of halogen atoms and trifluoromethyl group,
- which comprises dissolving a crude product containing the epoxy compound of the formula (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of water and an organic solvent, which is capable of phase-separating from water, obtaining the organic layer by phase separation, washing with pure water and then subjecting to isolation of the epoxy compound of the formula (1), wherein the washing of the organic layer with pure water is carried out until the electric conductivity of the separated aqueous layer reaches 30 mS/in or less.
The method of purifying the epoxy compound of the formula (1):
- wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an aromatic group optionally substituted with one or more substituents selected from the group consisting of halogen atoms and trifluoromethyl group,
- which comprises dissolving a crude product containing the epoxy compound of the formula (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of water and an organic solvent, which is capable of phase-separating from water, obtaining the organic layer by phase separation, washing with water and then subjecting to isolation of the epoxy compound of the formula (1), wherein the organic solvent is an aromatic hydrocarbon.
The method of purifying the epoxy compound of the formula (1):
- wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an aromatic group optionally substituted with one or more substituents selected from the group consisting of halogen atoms and trifluoromethyl group,
- which comprises dissolving a crude product containing the epoxy compound of the formula (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of water and an organic solvent, which is capable of phase-separating from water, obtaining the organic layer by phase separation, washing with water and then subjecting to isolation of the epoxy compound of the formula (1), wherein the washing of the organic layer with water is carried out until the content of the aprotic polar solvent in the organic layer after washing with water becomes 1 wt% or less.
Dependencies are inferred from the claim text.