Method of forming iron hydroxypyrone compounds
AssigneeVitra Pharmaceuticals Limited
InventorMichael A. Stockham
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Abstract
A method of forming an iron hydroxypyrone compound comprising reacting an iron salt of a carboxylic acid and a hydroxypyrone in an aqueous solution at a pH greater than 7.
Claims10
A method of forming an iron hydroxypyrone compound which is a ferric hydroxypyrone complex comprising hydroxypyrone and ferric iron in the stoichiometric ratio of 3:1 hydroxypyrone:
- ferric iron, which comprises the step of reacting one or more iron salt of a carboxylic acid and one or more hydroxypyrone in an aqueous solution at a pH greater than 7, wherein the aqueous solution comprises one or more base selected from the group consisting of alkali metal hydroxides, sodium or potassium carbonate and mixtures thereof, wherein the carboxylic acid is selected from the group consisting of citric acid, isocitric acid, succinic acid, fumaric acid, maleic acid, malonic acid, aconitic acid, glutaric acid, tartaric acid, gluconic acid, lactic acid, and mixtures thereof, wherein the hydroxypyrone is selected from the group consisting of maltol or ethyl maltol, and mixtures thereof;
- and wherein the concentration of the base is from 1 to 50% by weight of the aqueous solution.
A method of forming an iron hydroxypyrone compound which is a ferric hydroxypyrone complex comprising hydroxypyrone and ferric iron in the stoichiometric ratio of 3:1 hydroxypyrone:
- ferric iron, which comprises the step of adding one or more iron salt of a carboxylic acid in a solid form to a solution of one or more hydroxypyrone in an aqueous solution at a pH greater than 7, wherein the aqueous solution comprises one or more base selected from the group consisting of alkali metal hydroxides, sodium or potassium carbonate and mixtures thereof, wherein the carboxylic acid is selected from the group consisting of citric acid, isocitric acid, succinic acid, fumaric acid, maleic acid, malonic acid, aconitic acid, glutaric acid, tartaric acid, gluconic acid, lactic acid, and mixtures thereof, wherein the hydroxypyrone is selected from the group consisting of maltol or ethyl maltol, and mixtures thereof;
- and wherein the method comprises the step of adding the one or more iron salt of a carboxylic acid in a solid form to a solution of the one or more hydroxypyrone.
A method of forming an iron hydroxypyrone compound which is a ferric hydroxypyrone complex comprising hydroxypyrone and ferric iron in the stoichiometric ratio of 3:1 hydroxypyrone:
- ferric iron, which comprises the step of mixing a solution of one or more iron salt of a carboxylic acid with a solution of one or more hydroxypyrone in an aqueous solution at a pH greater than 7, wherein the aqueous solution comprises one or more base selected from the group consisting of alkali metal hydroxides, sodium or potassium carbonate and mixtures thereof, wherein the carboxylic acid is selected from the group consisting of citric acid, isocitric acid, succinic acid, fumaric acid, maleic acid, malonic acid, aconitic acid, glutaric acid, tartaric acid, gluconic acid, lactic acid, and mixtures thereof, wherein the hydroxypyrone is selected from the group consisting of maltol or ethyl maltol, and mixtures thereof;
- and wherein the method comprises the step of mixing a solution of the one or more iron salt of a carboxylic acid with a solution of the one or more hydroxypyrone.
Dependencies are inferred from the claim text.