1,2,4-oxadiazol-5-one-4-(benzimidazolylmethylamino)benzamidine compounds

A compound of formula (III)

• wherein:
• R1 is a C1-6-alkyl or C3-7-cycloalkyl group;
• and
• R2 is
• (i) a C1-6-alkyl group or a C3-7-cycloalkyl group optionally substituted by a C1-3-alkyl group, wherein the C1-3-alkyl group is optionally substituted by a carboxyl group or
• (ii) an R21NR22 group, wherein:
• R21 is a C1-6 alkyl group optionally substituted by a carboxy, C1-6 alkoxycarbonyl, benzyloxycarbonyl, C1-3-alkylsulfonylaminocarbonyl, phenylsulfonylaminocarbonyl, trifluorosulfonylamino, trifluorosulfonylaminocarbonyl, or 1H-tetrazolyl group, a C2-4-alkyl group substituted by a hydroxy, phenyl-C1-3-alkoxy, carboxy-C1-3-alkylamino, C1-3-alkoxycarbonyl-C1-3-alkylamino, N-(C1-3-alkyl)-carboxy-C1-3-alkylamino, or N-(C1-3-alkyl)-C1-3-alkoxycarbonyl-C1-3-alkylamino group, wherein the α-carbon atom to the adjacent nitrogen atom thereof is not substituted, or a piperidinyl group optionally substituted by a C1-3-alkyl group, and
• R22 is a hydrogen atom,
• a C1-6-alkyl group,
• a C3-7-cycloalkyl group optionally substituted by a C1-3-alkyl group,
• a C3-6-alkenyl, or C3-6-alkynyl group, wherein an unsaturated moiety of the C3-6-alkenyl or C3-6-alkynyl group is not linked directly to the nitrogen atom of the R21NR22 group,
• a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or by a C1-3-alkyl or C1-3-alkoxy group, or
• a benzyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, thienyl, or imidazolyl group optionally substituted by a C1-3-alkyl group;
• or
• R21 and R22 together with the nitrogen atom between them are a 5- to 7-membered cycloalkyleneimino group optionally substituted by a carboxy or C1-4-alkoxycarbonyl group, to which a phenyl ring is optionally additionally fused.