Back to results
US 7,459,565 B2Granted
Regiospecific process for the preparation of 4-[1- (4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl] benzonitrile
AssigneeSun Pharmaceutical Industries Limited
InventorsHetalkumar Virendrabhai Patel, Raja Jyotir Jani, Rajamannar Thennati
Life of this patent
Estimating the term…
Abstract
A regiospecific process for the preparation of 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile comprising reacting 4-halomethylbenzonitrile with 4-amino-1,2,4-triazole followed by deamination and reaction with 4-fluorobenzonitrile.
Claims12
A regiospecific process for preparation of 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile, a compound of formula 1,
- said process comprising:
- (a) reacting 4-halomethylbenzonitrile with 4-amino-1,2,4-triazole to give 4-[(4-amino-4H-1,2,4-triazolium-1-yl)methyl]benzonitrile halide, a compound of formula 2,
- deaminating the compound of formula 2 to 4-[1-(1H-1,2,4-triazol-1-yl)methylene]benzonitrile, a compound of formula 3,
- (c) reacting the compound of formula 3 with 4-fluorobenzonitrile.
1 more element
Dependencies are inferred from the claim text.