Method for producing cyclic diamine derivative or salt thereof
AssigneeKowa Company, Ltd.
InventorsKimiyuki Shibuya, Tadaaki Ohgiya, Toru Miura
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme: (wherein Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent; X represents NH, S, or O; ring A represents a benzene ring or a pyridine ring, which may have a substituent; 1 represents an integer of 1 or 2; m represents an integer of 1 or 2; and n represents an integer of 1 to 6). The method enables synthesis of a cyclic diamine compound (3) or a salt thereof, which serves as an ACAT inhibitor, in an industrially useful manner.
Claims18
A method for producing a cyclic diamine derivative represented by formula (3)
- or a salt thereof, comprising:
- reacting a compound represented by formula (1):
- with a thiol derivative represented by formula (2a) or (2b):
- in the presence of a phosphorus compound, wherein
- Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent;
- X represents NH, S, or O;
- ring A represents a benzene ring or a pyridine ring, which may have a substituent;
- 1 represents an integer of 1 or 2;
- m represents an integer of 1 or 2;
- and n represents an integer of 1 to 6, and
- the phosphorus compound is a reagent selected from the group consisting of a phosphine reagent, a phosphorus reagent formed of a phosphine and an azo compound, a phosphorus reagent formed of a phosphine and an ethylenedicarboxylic acid and a phosphonium ylide reagent.
Dependencies are inferred from the claim text.