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US 7,459,546 B2Granted
Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
AssigneeE.I. du Pont de Nemours and Company
InventorsStephen K. Picataggio, Quinn Qun Zhu
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Abstract
The regulatory sequences associated with the Yarrowia lipolytica glyceraldehyde-3-phosphate dehydrogenase (gpd) and phosphoglycerate mutase (gpm) genes have been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the invention, intron and enhancer have been shown to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.
Claims2
An isolated nucleic acid molecule comprising the intron of the Yarrowia gpd gene as set forth in SEQ ID NO:97.
Dependencies are inferred from the claim text.