Human GIL-19/AE289 proteins
AssigneeGenetics Institute, Inc.
InventorsKenneth Jacobs, Lynette Fouser, Vikki Spaulding, Dejun Xuan
Life of this patent
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Abstract
Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
Claims11
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:2;
- and
- (b) amino acid 34-179 of SEQ ID NO:2;
- and
- (c) the amino acid sequence encoded by the cDNA insert of clone hGIL-19/AE289 deposited under accession number ATCC 207231.
An isolated protein comprising one or more fragments of SEQ ID NO:2, wherein the one or more fragments comprise amino acids 50-60 of SEQ ID NO:2, amino acids 63-81 of SEQ ID NO:2, and amino acids 168-177 of SEQ ID NO:2.
An isolated protein, comprising an amino acid sequence which is at least 95% identical to SEQ ID NO:2 wherein said protein is capable of inducing the phosphorylation of a Stat-3 protein.
Dependencies are inferred from the claim text.