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US 7,459,529 B2Granted
AIMP2-DX2 and its uses
AssigneeSeoul National University Industry Foundation
InventorSunghoon Kim
Life of this patent
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Abstract
The present invention relates to a variant of AIMP2 lacking exon 2, named as AIMP2-DX2, which is specifically expressed in cancer cells. The AIMP2-DX2 protein and gene can be successfully used in the development of diagnosis and treatment of cancer.
Claims3
An isolated AIMP2-DX2 protein comprising the amino acid sequence of SEQ ID NO:2.
A method of screening for an agent which inhibits the formation of a heterodimer between the AIMP2-DX2 protein and the AIMP2 protein, comprising the steps of:
- (a) contacting a test substance to a composition which comprises the AIMP2-DX2 protein of SEQ ID NO:2 and the AIMP2 protein;
- and
- (b) determining whether the test substance inhibits the heterodimer formation between the AIMP2-DX2 protein and the AIMP2 protein,
- wherein the test substance to inhibit the heterodimer formation between the AIMP2-DX2 protein and the AIMP2 protein is evaluated as an anticancer agent.
1 more element
Dependencies are inferred from the claim text.