Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

A compound of formula II:

• wherein:
• X is hydrogen, an alkali metal or a basic amine moiety;
• R1 is C1-C8 alkyl, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl, wherein the rings of the cycloalkyl, pyridinyl, phenyl and benzyl groups may be optionally substituted by from 1 to 3 groups selected from halogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, —O—C1-C6 perfluoroalkyl, C1-C6 alkoxy, —OH, —NH2, or —NO2;
• R2 is hydrogen, halogen, C1-C6 alkyl, C1-C3 perfluoroalkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, —CH2—C3-C6 cycloalkyl, hydroxy, —NH2, or —NO2;
• R3 is hydrogen, halogen, C1-C6 alkyl, C1-C3 perfluoroalkyl, C1-C6 alkoxy, C3-C6cycloalkyl, —CH2—C3-C6 cycloalkyl, hydroxy, —NH2, —NO2, phenyl, benzyl, benzyloxy, pyridinyl, or —CH2-pyridinyl, wherein the rings of these groups may be optionally substituted by from 1 to 3 groups selected from phenyl, halogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 alkoxy, —OH, —NH2, or —NO2;
• or a pharmaceutically acceptable salt or ester form thereof.