Aryl and heteroaryl compounds, compositions, and methods of use

The compound of Formula (I):

• wherein
• c is equal to 0, 1, or 2;
• wherein —CH2—, and —CH2—CH2—, optionally substituted 1 to 4 times with substituent(s) independently selected from the group consisting of:
• -alkyl, -aryl, -alkylene-aryl, -arylene-alkyl, -alkylene-arylene-alkyl, —O-alkyl, —O-aryl, and -hydroxyl;
• G is:
• a substituted oxadiazole:
• wherein R7 is alkyl, aryl, alkylene-sulfonyl-alkyl or alkylene-sulfonyl-aryl;
• wherein
• V is:
• —(CH2)b—O—(CH2)a—, —(CH2)b—N(R8)—(CH2)a—, —(CH2)b—O—, —(CH2)b—N(R8), —(CH2)a—, —CH═CH—(R8)— or a direct bond;
• in which a is equal to 0,1, or 2, b is equal to 1 or 2, and R8 is:
• -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, or -alkylene-arylene-alkyl;
• wherein the —CH2— groups may be optionally substituted 1 to 4 times with a substituent selected from the group consisting of:
• -alkyl, -aryl, -alkylene-aryl, -arylene-alkyl, -alkylene-arylene-alkyl, —O-alkyl, —O-aryl, -hydroxyl, —S-alkyl, and —S-aryl;
• X is:
• —N(R9)—, -CON(R9)—, —N(R9)CO—, —N(R9)CON(R10)—, —OC(O)N(R8)—, —SO2N(R9)—, —N(R9)SO2—, or —N(R9)SO2N(R10)—;
• wherein R9 and R10 are independently selected from the group consisting of:
• -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, -alkylene-arylene-alkyl, and —(CH2)dY—, wherein d is equal to 0, 1, or 2,
• wherein
• Y is:
• -hydrogen, —CO2R11, —CH2OR11, —C(O)—R11, —C(O)NR11R12, —C(R11)═N—O—R12, —NR11R12, or an acid isostere;
• wherein R11 and R12 independently selected from the group consisting of:
• -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, -alkylene-arylene-alkyl, -heterocyclyl, or -heteroaryl;
• Ar1 is an aryl, or fused cycloalkylaryl, wherein Ar1 is optionally substituted 1 to 7 times with substituent(s) independently selected from the group consisting of:
• a) -fluoro;
• b) -chloro;
• c) -bromo;
• d) -iodo;
• e) -cyano;
• f) -nitro;
• g) -perfluoroalkyl;
• h) -D-R12;
• i) -alkyl;
• j) -aryl;
• k) -cycloalkyl;
• l) -alkylene-aryl;
• m) -alkylene-arylene-aryl;
• n) -alkylene-arylene-alkyl;
• o) -arylene-alkyl;
• p) -arylene-arylene-alkyl;
• q) -D-alkyl;
• r) -D-aryl;
• s) -D-alkylene-aryl;
• t) -D-arylene-alkyl;
• u) -D-alkylene-arylene-aryl;
• v) -D-arylene-arylene-aryl;
• w) -D-alkylene-arylene-alkyl;
• x) -alkylene-D-alkylene-aryl;
• y) -arylene-D-alkyl;
• z) -alkylene-D-aryl;
• aa) -alkylene-D-cycloalkyl;
• bb) -alkylene-D-arylene-alkyl;
• cc) -alkylene-D-alkylene-arylene-alkyl;
• dd) -alkylene-D-alkyl;
• ee) -alkylene-D-R13;
• ff) -arylene-D-R13;
• and
• gg) -hydrogen;
• wherein D is —CH2—, —O—, —N(R14)—, —C(O)—, —CON(R14)—, —N(R14)C(O)—, —N(R14)CON(R15)—, —N(R14)C(O)O—, —OC(O)N(R14)—, —N(R14)SO2—, —SO2N(R14)—, —C(O)—O—, —O—C(O)—, —S—, —S(O)—, —S(O2)—, —N(R14)SO2N(R15)—,
• wherein
• R13, R14, R15, and R16 are independently selected from the group consisting of:
• -hydrogen, hydroxyl, -cyano, nitro, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, and -alkylene-arylene-alkyl;
• and
• Ar2 is an aryl group, wherein Ar2 is optionally substituted 1 to 7 times with substituent(s) independently selected from the group consisting of:
• a) -fluoro;
• b) -chloro;
• c) -bromo;
• d) -iodo;
• e) -cyano;
• f) -nitro;
• g) -perfluoroalkyl;
• h) -T-R17;
• i) -alkyl;
• j) -aryl;
• k) -cycloalkyl;
• l) -alkylene-aryl;
• m) -alkylene-arylene-aryl;
• n) -alkylene-arylene-alkyl;
• o) -arylene-alkyl;
• p) -arylene-arylene-alkyl;
• q) -T-alkyl;
• r) -T-aryl;
• s) -T-alkylene-aryl;
• t) -T-arylene-alkyl;
• u) -T-alkylene-arylene-aryl;
• v) -T-arylene-arylene-aryl;
• w) -T-alkylene-arylene-alkyl;
• x) -alkylene-T-alkylene-aryl;
• y) -arylene-T-alkyl;
• z) -alkylene-T-aryl;
• aa) -alkylene-T-cycloalkyl;
• bb) -alkylene-T-arylene-alkyl;
• cc) -alkylene-T-alkylene-arylene-alkyl;
• dd) -alkylene-T-alkyl;
• ee) -alkylene-T-R17;
• ff) -arylene-T-R17;
• or
• gg) -T-fused cycloalkylaryl;
• and
• hh) -T-fused arylcycloalkyl;
• wherein
• T is a direct bond, —CH2—, —O—, —N(R18)—, —C(O)—, —CON(R18)—, —N(R18)C(O)—, —N(R18)CON(R19)—, —N(R18)C(O)O—, —OC(O)N(R18)—, —N(R18)SO2—, —SO2N(R18)—, —C(O)—O—, —O—C(O)—, —S—, —S(O)—, —S(O2)—, —N(R18)SO2N(R19)—,
• wherein R17, R18, R19 and R20, are independently selected from the group consisting of:
• -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, and -alkylene-arylene-alkyl;
• and wherein
• the alkyl, aryl, alkylene, and arylene groups in Ar1, Ar2, G, R1-R21, may be optionally substituted 1 to 4 times with substituent(s) independently selected from the group consisting of:
• a) -hydrogen;
• b) -fluoro;
• c) -chloro;
• d) -bromo;
• e) -iodo;
• f) -cyano;
• g) -nitro;
• h) -perfluoroalkyl;
• i) -Q-R22;
• j) -Q-alkyl;
• k) -Q-aryl;
• l) -Q-alkylene-aryl;
• m) -Q-alkylene-NR23R24;
• and
• n) -Q-alkyl-W-R25;
• wherein
• Q and W are independently selected from the group consisting of:
• —CH2—, —O—, —N(R26)—, —C(O)—, —CON(R26)—, —N(R26)C(O)—, —N(R26)CON(R27)—, —N(R26)C(O)O—, —OC(O)N(R26)—, —N(R26)SO2—, —SO2N(R26)—, —C(O)—O—, —O—C(O)—, and —N(R26)SO2N(R27)—, wherein
• R22, R23, R24, R25, R26 and R27, are independently selected from the group consisting of:
• -hydrogen, -alkyl, -aryl, -arylene-alkyl, -alkylene-aryl, and -alkylene-arylene-alkyl,
• or a pharmaceutically acceptable salt thereof.