Inclusion compound comprising cucurbituril derivatives as host molecule and pharmaceutical composition comprising the same
AssigneePostech Foundation
InventorsKimoon Kim, Young Jin Jeon, Soo Young Kim, Young Ho Ko
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Abstract
The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical composition having an anticancer effect can be obtained by using the inclusion compound according to the present invention. The pharmaceutical composition can prevent effective components from being biologically degraded in vivo and can exhibit continuous drug effect for a long time just by a single dosage by controlling the release time of the platinum complex once it reaches target tumor cells.
Claims10
An inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule:
- wherein R1 and R2 are independently selected from the group consisting of H, C1-C30 alkyl, C1-C30 alkene, C1-C30 alkyne, C1-C30 alkylthio, C1-C30 alkylcarboxy, C1-C30 alkylhydroxy, C1-C30 alkylsilyl, C1-C30 alkyloxy, C1-C30 haloalkyl, nitro, C1-C30 alkylamine, amine, C5-C30 unsubstituted cycloalkyl or C5-C30 cycloalkyl having a hetero atom, and C6-C15 unsubstituted aryl or C6-C15 aryl having a hetero atom, n is an integer from 4 to 20, M is a divalent or quartemary metal ion selected from the group consisting of transition metals, lanthanide metals, actinide metals, alkali metals and alkali earth metals, X1 and X2 meet one selected from the following conditions (i) and (ii):
- (i) X1 and X2 are independently selected from the group consisting of halogen atom, C1-C30 haloalkyl, hydroxy, C1-C30 alkylcarboxy, and C1-C30 alkyldicarboxy;
- or (ii) X1 and X2 are interconnected to each other and are one among components represented by the structural formulas (a) through (h):
- X3 and X4 meet one selected from the following conditions (i) and (ii):
- (i) when M is a divalent metal ion, X3 and X4 denote non-bonding;
- or (ii) when M is a quaternary metal ion, X3 and X4 are independently selected from the group consisting of halogen atom, C1-C30 haloalkyl, hydroxy, C1-C30 alkylcarboxy, and C1-C30 alkyldicarboxy, R3, R4, R5, R6, R7 and R8 meet one selected from the following conditions (i), (ii) and (iii):
- (i) R3, R4, R5, R6, R7 and R8 are independently selected from the group consisting of H, C1-C30 alkyl, C1-C30 alkene, C1-C30 alkyne, C1-C30 alkylthio, C1-C30 alkylcarboxy, C1-C30 alkylhydroxy, C1-C30 alkylsilyl, C1-C30 alkyloxy, C1-C30 haloalkyl, nitro, C1-C30 alkylamine, amine, C6-C30 unsubstituted cycloalkyl or C5-C30 cycloalkyl having a hetero atom, and C6-C15 unsubstituted aryl or C6-C15 aryl having a hetero atom;
- (ii) R3, R4, R7 and R8 are independently selected from the group consisting of H, C1-C30 alkyl, C1-C30 alkene, C1-C30 alkyne, C1-C30 alkylthio, C1-C30 alkylcarboxy, C1-C30 alkylhydroxy, C1-C30 alkylsilyl, C1-C30 alkyloxy, C1-C30 haloalkyl, nitro, C1-C30 alkylamine, amine, C6-C30 unsubstituted cycloalkyl or C5-C30 cycloalkyl having a hetero atom, and C6-C15 unsubstituted aryl or C6-C15 aryl having a hetero atom, and R5 and R6 are interconnected to each other and one among components represented by the structural formulas (i) through (q):
- and
- (iii) R3, R4 and R8 are independently selected from the group consisting of H, C1-C30 alkyl, C1-C30 alkene, C1-C30 alkyne, C1-C30 alkylthio, C1-C30 alkylcarboxy, C1-C30 alkylhydroxy, C1-C30 alkylsilyl, C1-C30 alkyloxy, C1-C30 haloalkyl, nitro, C1-C30 alkylamine, amine, C6-C30 unsubstituted cycloalkyl or C5-C30 cycloalkyl having a hetero atom, and C6-C15 unsubstituted aryl or C6-C15 aryl having a hetero atom, and R5 and R6, and R6 and R7 are interconnected to each other and represented by the structural formula (o) wherein asterisk denotes a position bonded with N:
Dependencies are inferred from the claim text.