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US 7,459,468 B2Granted
Aryl sulfonic pyridoxines as antiplatelet agents
AssigneeMedicure International Inc.
InventorsWasimul Haque, James Diakur
Life of this patent
Estimating the term…
Abstract
Aryl sulfonic pyridoxine compounds with antiplatelet aggregation characteristics for the treatment of cardiovascular and cardiovascular related disease, are described. The methods are directed to administering pharmaceutical compositions comprising aryl sulfonic pyridoxines.
Claims36
A compound of the formula:
- wherein
- A)
- R1 is —OH;
- —O-alkyl;
- —(CH2)n′OH where n′ is an integer from 1 to 8;
- alkyl;
- cycloalkyl;
- or O-alkyl-aryl-R4, where R4 is —CN or amidine;
- R2 is (CH2)n-aryl-R5 where n is an integer from 0 to 8 and R5 is SO2NH2 or SO2NHC(CH3)3;
- (CH2)n-aryl-aryl-R5, where n and R5 are as defined above, or —(CH2)n—NH-aryl-R5, where n and R5 are as defined above;
- and
- R3 is —(CH2)nOH where n is as defined above;
- (CH2)n—NH-aryl-R5, where n and R5 are as defined above;
- (CH2)n—NH—CO-aryl-R5 where n and R5 are as defined above;
- (CH2)n—NH-aryl-aryl-R5 where n and R5 are as defined above;
- or (CH2)n—NH—CO-aryl-aryl-R5 where n and R5 are as defined above;
- or
- B)
- R1 is —OH;
- —O-alkyl;
- —(CH2)n′OH where n′ is an integer from 1 to 8;
- alkyl;
- cycloalkyl;
- or O-alkyl-aryl-R4, where R4 is —CN or amidine;
- R2 is alkyl;
- —(CH2)n′OH where n′ is as defined above;
- —(CH2)nCOOH where n is an integer from 0 to 8;
- —(CH2)nCOO(CH2)nCH3 where n is as defined above;
- (CH2)n-aryl-R5 where n is as defined above and R5 is SO2NH2 or SO2NHC(CH3)3;
- (CH2)n-aryl-aryl-R5, where n and R5 are as defined above, or —(CH2)n-NH-aryl-R5, where n and R5 are as defined above;
- R3 is (CH2)n—NH-aryl-R5, where n and R5 are as defined above;
- (CH2)n—NH—CO-aryl-R5 where n and R5 are as defined above;
- (CH2)n—NH-aryl-aryl-R5 where n and R5 are as defined above;
- or (CH2)n—NH—CO-aryl-aryl-R5 where n and R5 are as defined above
- and
- R1 and R2 when taken together form a compound of formula II,
- wherein R3 is as defined above;
- or a pharmaceutically acceptable salt thereof.
35 more elements
A compound of the formula
- wherein
- R1 is OH, OCH3, or OCH2—(4-tert-Butyl-phenyl), or
- R2 is CH2OH or
- where R8 is as defined above;
- W is (CH2)n where n′=1, 2 or 3;
- X is (CH2)n where n=0, 1, 2, or 3, or C═O;
- Y is C—H, C—F, or N;
- and
- R1 and R2 when taken together form a compound of formula
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.