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US 7,459,464 B2Granted
Triple monoamine reuptake inhibitors for the treatment of chronic pain
AssigneeNeuroSearch A/S
InventorsJørgen Scheel-Krüger, Gordon John Blackburn-Munro
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Abstract
The present invention relates to the use of triple monoamine reuptake inhibitors for the treatment of chronic pain.
Claims6
A method for the treatment or alleviation of a chronic pain condition in a subject comprising:
- administering to said subject a therapeutically effective amount of a triple monoamine reuptake inhibitor wherein the triple monoamine reuptake inhibitor is a compound of formula (I)
- or a pharmaceutically acceptable addition salt thereof or the N-oxide thereof,
- wherein the chronic pain condition is selected from at least one of the group of chronic pain conditions consisting of:
- inflammatory pain, neuropathic pain, fibromyalgia and tension-type headache, and
- wherein
- R is hydrogen or methyl;
- R3is —CH2—O—R′, wherein R′ is methyl, ethyl or propyl;
- and
- R4is 3,4-dichlorophenyl.
6 more elements
A method for the treatment or alleviation of a chronic pain condition in a subject comprising:
- administering to said subject a therapeutically effective amount of (1R,2R,3S)-2-Ethoxymethyl-3-(3,4-dichlorophenyl)-tropane;
- or a pharmaceutically acceptable addition salt thereof,
- wherein the chronic pain condition is selected from at least one of the group of chronic pain conditions consisting of:
- inflammatory pain, neuropathic pain, fibromyalgia and tension-type headache.
1 more element
A method for the treatment or alleviation of a chronic pain condition in a subject comprising:
- administering to said subject a therapeutically effective amount of
- (1R,2R,3S)-N-Normethyl-2-methoxymethyl-3-(3,4-dichlorophenyl)-tropane;
- or a pharmaceutically acceptable addition salt thereof,
- wherein the chronic pain condition is selected from at least one of the group of chronic pain conditions consisting of:
- inflammatory pain, neuropathic pain, fibromyalgia and tension-type headache.
2 more elements
Dependencies are inferred from the claim text.