Polycyclic pyridines as potassium ion channel modulators

A compound having a structure according to Formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein
• A is substituted or unsubstituted pyridinyl or substituted or unsubstituted pyrazinyl, wherein the pyridinyl and pyrazinyl are substituted with from 1-4 R1 substituents;
• B is
• wherein
• R7A is independently H, —OH, —NH2, —NO2, —SO2NH2, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7- membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7B is independently H or substituted or unsubstituted alkyk;
• and
• y is an integer from 1 to 4, wherein two R7A groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted 5- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted aryl;
• X is a bond or —NR4—;
• k is an integer from 1 to 3;
• R1 and R2 are independently H, —OH, —NH2, —NO2, —SO2NH2, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7- membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7- membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and
• wherein
• the substituents for alkyl and heteroalkyl are selected from the group consisting of —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, —CO2R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O)2R′, —NR—C(NR′R″R′″)═NR″″, —NR—C(NR′R″)═NR′″, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NRSO2R′, —CN and —NO2 in a number ranging from zero to (2m′+1), where m′ is the total number of carbon atoms in such radical, wherein R′, R″, R′″ and R″″ are each independently refer to hydrogen, unsubstituted heteroalkyl, unsubstituted aryl, unsubstituted alkyl, alkoxy or thioalkoxy groups, or arylalkyl groups;
• and
• the substituents for aryl and heteroaryl are selected from the group consisting of halogen, —OR′, —NR′R″, —SR, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, -CO2R′, —CONR′R″, —OC(O)NR′R″, —NR′C(O)R′, —NR′—C(O)NR′R″, —NR′C(O)2R′, —NR′—C(NR′R″R′″)═NRW, —NR′—C(NR′R″)═NR′″, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NRSO2R′, —CN and —NO2, —R′, —N3, —CH(Ph)2, fluoro(C1-C4)alkoxY, and fluoro(C1-C4)alkyl, in a number ranging from zero to the total number of open valences on the aromatic ring system;
• and where R′,R″,R′″ and RW are independently selected from hydrogen, alkyl, heteroalkyl, aryl and heteroaryl,
• wherein if k is greater than one, then each R2 is optionally different.