Pyrimidine compounds

A compound of Formula (I):

• or a salt thereof:
• wherein:
• W is C—R, wherein R is hydrogen, halogen, or cyano;
• J is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aralkyl, cyanoalkyl, —(CH2)pC═CH(CH2)tH, —(CH2)pC≡C(CH2)tH, or C3-C7 cycloalkyl;
• p is 1, 2, or 3;
• t is 0 or 1;
• D is
• q is 1, 2, or 3;
• Q1 is hydrogen, halogen, C1-C2 haloalkyl, C1-C2 alkyl, C1-C2 alkoxy, or C1-C2 haloalkoxy;
• Q2 is A1 or A2;
• Q3 is A1 when Q2 is A2 and Q3 is A2 when Q2 is A1;
• wherein
• A1 is hydrogen, halogen, C1-C3 alkyl, C1-C3 haloalkyl, —OR1, and
• A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein
• Z is CH2 and m is 0, 1, 2, or 3, or
• Z is NR2 and m is 0 or 1, or
• Z is O and m is 0 or 1, or
• Z is CH2NR2 and m is 0 or 1;
• Z1 is S(O)2, S(O), or C(O);
• and
• Z2 is C1-C4 alkyl, cycloalkyl, heterocyclyl, NR3R4, aryl, arylamino, aralkyl, aralkoxy, or heteroaryl;
• R2, R3, and R4 are each independently selected from hydrogen, hydroxy, alkoxy, aryloxy, aralkoxy, amino, alkylamino, arylamino, aralkylamino, C1-C4 alkyl, C3-C7 cycloalkyl, heterocyclyl, —S(O)2R5, and —C(O)R5;
• R5 is C1-C6 alkyl, or C3-C7 cycloalkyl;
• and
• R6 is the group defined by —(X4)z—(X5), wherein
• X4 is C(H)2 where z is 0, 1, 2, 3, or 4, and
• X5 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkoxy, haloalkoxy, hydroxy, aryloxy, aralkoxy, halo, CN, —NR7R7, —N(H)C(O)R7, —N(H)C(O)OR7, —N(H)C(O)NR7R7, N(H)S(O)2R7, N(H)S(O)2NR7R7, —OC(O)R7, OC(O)NR7R7, —C(O)R7, —C(O)NR7R7, —SR7, —S(O)R7, S(O)2R7R7, —or S(O)2NR7R7;
• and
• R7 is hydrogen, C1-C6 alkyl, C1-C2 haloalkyl, cycloalkyl, heterocyclyl, alkylamino, alkoxy, aryloxy, aralkoxy, arylamino, aralkylamino, aryl or heteroaryl.