Lactam compounds useful as protein kinase inhibitors

A compound of formula (V):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• Ring A is substituted with 0-2 Rh and 0-2 R8h;
• Ring B is substituted with 0-2 Rj and 0-2 R8j;
• G1 is C═O, C═S, or S(═O)2;
• Y1 is N or CH;
• Y2 is N or CRe;
• Rb is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group;
• Rc is hydrogen, fluoro, —OR5, —N(R4)2, or an optionally substituted C1-4aliphatic;
• Rd is hydrogen, fluoro, or C1-4aliphatic;
• or Rc and Rd taken together with the carbon atom to which they are attached, form an optionally substituted 3- to 6-membered carbocycic ring;
• Re is hydrogen, halo, C1-4aliphatic, C1-4fluoroaliphatic, —Re, -T3-R1e, -T3-R2e, -V2-T3-R1e, or -V2-T3-R2c;
• T3 is a C1-4alkylene chain optionally substituted with one or two R3;
• V2 is —C(R5)═C(R5)— or —C≡C—;
• R1e is an optionally substituted aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring;
• R2e is —NO2, —CN, —C(R5)═C(R5)2, —C(R5)═C(R5)(R10), —C≡C—R5, —C≡C—R10, —OR5, —N(R4)2, —NR4C(O)R5, —NR4C(O)N(R4)2, —NR4CO2R6, —CO2R5, —C(O)R5, —C(O)N(R4)2, —N(R4)SO2R6, or —N(R4)SO2N(R4)2;
• each Rh independently is selected from the group consisting of C1-6aliphatic, C1-6fluoroaliphatic, halo, —R1h, —R2h, -T4-R2h, -T4-R1h, and -V3-T4-R2h, or two adjacent Rh, taken together with the intervening ring atoms, form an optionally substituted fused 4- to 8-membered aromatic or non-aromatic ring having 0-3 ring heteroatoms selected from the group consisting of O, N, and S;
• T4 is a C1-6alkylene chain optionally substituted with one or two independently selected R3a or R3b, wherein the alkylene chain optionally is interrupted by —C(R5)═C(R5)—, —C≡C—, —O—, —S—, —S(O)—, —S(O)2—, —SO2N(R4)—, —N(R4)—, —N(R4)C(O)—, —NR4C(O)N(R4)—, —N(R4)CO2—, or —SO2N(R4);
• V3 is —C(R5)═C(R5)—, —C≡C—, —O—, —S—, —S(O)—, —S(O)2—, —SO2N(R4)—, —N(R4)—, —N(R4)C(O)—, —NR4C(O)N(R4)—, —N(R4)CO2—, —C(O)N(R4)—, —C(O)—, —C(O)—C(O)—, —CO2—, —OC(O)—, —OC(O)O—, —OC(O)N(R4)—, —C(NR4)═N—, —C(OR5)═N—, —N(R4)SO2—, —N(R4)SO2N(R4)—, —P(O)(R5)—, —P(O)(OR5)—O—, —P(O)—O—, or —P(O)(NR5)—;
• each R1h independently is an optionally substituted aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring;
• each R2h independently is —NO2, —CN, —C(R5)═C(R5)2, —C≡C—R5, —C(R5)═C(R5)(R10), —C≡C—R10, —OR5, —SR6, —S(O)R6, —SO2R6, —SO3R5, —SO2N(R4)2, —N(R4)2, —NR4C(O)R5, —NR4C(O)N(R4)2, —NR4COR6, —O—CO2R5, —OC(O)N(R4)2, —O—C(O)R5, —CO2R5, —C(O)—C(O)R5, —C(O)R5, —C(O)N(R4)2, —C(O)N(R4)C(═NR4)—N(R4)2, —N(R4)C(═NR4)—N(R4)—C(O), —C(═NR4)—N(R4)2, —C(═NR4)—OR5, —C(R6)═N—OR5, —N(R4)C(═NR4)—N(R4)2, —N(R4)SO2R6, —N(R4)SO2N(R4)2, —P(O)(O)R5)2;
• each Rj independently is selected from the group consisting of C1-6aliphatic, C1-6fluoroaliphatic, halo, —R1j, —R2j, -T5-R2j, -T5-R1j, -V4-T5-R1j, and -V4-T5-R2j;
• or two adjacent Rj, taken together with the intervening ring atoms, form an optionally substituted fused 4- to 8-membered aromatic or non-aromatic ring having 0-3 ring heteroatoms selected from the group consisting of O, N, and S;
• T5 is a C1-6alkylene chain optionally substituted with one or two independently selected R3a or R3b, wherein the alkylene chain optioxtally is interrupted by —C(R5)═C(R5)—, —C≡C—, —O—, —S—, —S(O)—, —S(O)2—, —SO2N(R4)—, —N(R4)—, —N(R4)C(O)—, —NR4C(O)N(R4)—, —N(R4)CO2—, —C(O)N(R4)—, —C(O)—, —C(O)—C(O)—, —CO2—, —OC(O)—, —OC(O)O—, —OC(O)N(R4)—, —N(R4)SO2—, or —SO2N(R4);
• V4 is —C(R5)═C(R5)—, —C≡C—;
• —O—, —S—, —S(O)—, —S(O)2—, —SO2N(R4)—, —N(R4)—, —N(R4)C(O)—, —OC(O)O—, —OC(O)N(R4)—, —C(NR4)═N—, —C(OR5)═N—, —N(R4)SO2—, —N(R4)SO2N(R4)—, —P(O)(R5)—, —P(O)(OR5)—O—, —P(O)—O—, or —P(O)(NR5)—N(R5)—;
• each R1j independently is an optionally substituted aryl, heteroayl, heterocyclyl, or cycloaliphatic ring;
• each R2j independently is —NO2, —CN, —C(R5)═C(R5)2, —C≡C—R5, —C(R5)═C(R5)(R10), —C≡C—R10, —OR5, —SR6, —S(O)R6, —SO2R6, —SO3R5, —SO2N(R4)2, —N(R4)2, —NR4C(O)R5, —NR4C(O)N(R4)2, —NR4CO2R6, —O—CO2R5, —OC(O)N(R4)2, —O—C(O)R5, —CO2R5, —C(O)—C(O)R5, —C(O)R5, —C(O)N(R4)2, —C(O)N(R4)C(═NR4)—N(R4)2, —N(R4)—C(═NR4)—N(R4)—C(O), —C(═NR4)—N(R4)2, —C(═NR4)—OR5, —N(R4)C(═NR4)—N(R4)2, —N(R4)SO2R6, —N(R4)SO2N(R4)2, —P(O)(R5)2, or —P(O)(OR5)2;
• each R3 independently is selected from the group consisting of C1-3aliphatic, —F, —OH, and —O(C1-3alkyl), or two substituents R3 on the same carbon atom, taken together with the carbon atom to which they are attached, form a 3- to 6-membered carbocyclic ring;
• each R3a independently is selected from the group consisting of —F, —OH, —O(C1-3alkyl), —CN, —N(R4)2, —C(O)(C1-3alkyl), —CO2H, —CO2(C1-3alkyl), —C(O)NH2, and —C(O)NH(C1-3alkyl);
• each R3b independently is a C1-3aliphatic optionally substituted with R3a or R7, or two substituents R3b on the same or adjacent carbon atom(s) taken together with the carbon atom(s) to which they are attached, form a 3- to 6-membered carbocyclic ring;
• and
• each R4 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group;
• or two R4 on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms selected from N, O, and S;
• each R4a independently is hydrogen or an optionaLly substituted aliphatic, aryl, heteroaryl, or heterocyclyl group;
• or two R4a on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatonis selected from N, O, and S;
• each R5 independently is hydrogen or an optionallysubstituted aliphatic, aryl, heteroaryl, or heterocyclyl group;
• each R5a independently is hydrogen or an optio mally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group;
• each R6 independently is an optionally substituted aliphatic or aryl group;
• each R6a independently is an optionally substituted aliphatic or aryl group;
• each R7 independently is an optionally substituted aryl or heteroaryl ring.
• each R8h independently is selected from the group consisting of C1-4aliphatic, C1-4fluoroaliphatic, -halo, and —O(C1-4aliphatic);
• each R8j independently is selected from the group consisting of C1-4aliphatic, C1-4fluoroaliphatic, -halo, —CO2H, —CO2(C1-4aliphatic), —OH, and —O(C1-4aliphatic);
• and
• R10 is —CO02R5 or —C(O)N(R4)2.