Modification of feeding behavior
AssigneesImperial College Innovations Limited, Oregon Health & Science University
InventorsMichael Cowley, Roger Cone, Malcolm Low, Andrew Butler, Stephen Robert Bloom, Caroline Jane Small, Rachel Louise Batterham, Mohammad Ali Ghatel
Life of this patent
Estimating the term…
Abstract
Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.
Claims18
A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject.
A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:334) in a dosage of from about 45 to about 135 pmol per kilogram body weight of said subject.
A method for treating obesity in a human subject in need of treatment comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:334) in a dose of from 5 to 100 nmoles per 70-75 kg body weight of said subject.
A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising administering prior to a meal to said subject PYY3-36 (SEQ ID NO:334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject by a rectal, intravenous, intramuscular, intranasal, intraperitoneal, intravaginal, transmucosal, sublingual or buccal route, or by pulmonary inhalation.
A method for treating obesity in a human subject in need thereof, comprising administering prior to a meal to said subject PYY3-36 (SEQ ID NO:334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject by a rectal, intravenous, intramuscular, intranasal, intraperitoneal, intravaginal, transmucosal, sublingual or buccal route, or by pulmonary inhalation.
Dependencies are inferred from the claim text.