Peptide inhibitors of protein kinase C γ for pain management
AssigneeThe Borad of Trustees of the Leland Stanford Junior University
InventorsDaria Mochly-Rosen, Sarah M. Sweitzer, Joan J. Kendig, David C. Yeomans
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Abstract
Peptide sequences derived from the V5 domain of isozymes of protein kinase C for use in pain management are described. Also described are compositions comprising the peptides for treating pain and/or inducing analgesia. Methods of pain treatment and methods of identifying compounds that mimic the activity of the peptides are also described.
Claims8
An isolated peptide consisting of a gamma-protein kinase C (γPKC) peptide, wherein the peptide consists of between five and ten amino acid residues having at least 80% sequence identity to SEQ ID NO:4, said γPKC peptide having isozyme-specific activity for modulation of pain, and wherein the γPKC peptide is conjugated to a heterologous carrier peptide for transport across a cell membrane.
Dependencies are inferred from the claim text.