Method for analysing macromolecules

A method for analyzing macromolecules comprising the steps of:

• locating a plurality of first at least partly different macromolecules in a known arrangement on a microarray comprising a specific region wherein the specific region has different wetting properties from its surrounding regions on the microarray such that a liquid comprising a plurality of second macromolecules can reside on the specific region,
• arranging the microarray on a solid surface and loading the liquid comprising the plurality of the second macromolecules onto a region of the microarray,
• launching a surface wave and distributing the liquid on the microarray with the aid of the surface wave such that the plurality of the second macromolecules are moved to the specific region and interact with the first at least partly different macromolecules,
• after a period of time, removing the liquid from the specific region on the microarray, and
• analyzing the second macromolecules remaining on the specific region after the removal step and determining the positions of the first at least partly different macromolecules on the specific region of the microarray wherein the first at least partly different macromolecules form bonds with the second macromolecules remaining on the specific region after the removal step and wherein the first at least partly different macromolecules comprises different oligonucleotides and/or different proteins and/or different antigens and/or different antibodies.