Active truncated form of the RNA polymerase of flavivirus
AssigneeCentre National de la Recherche Scientifique (CNRS)
InventorsJean-Louis Romette, Bruno Canard, Marie-Pierre Egloff, Barbara Selisko, Delphine Benarroch
Life of this patent
Estimating the term…
Abstract
The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.
Claims5
An isolated and purified polypeptide from a flavivirus having polymerase activity, wherein the full-length amino acid sequence of said polypeptide has at least 80% of identity with the SEQ ID NO:
- 16.
An isolated and purified polypeptide from a flavivirus having polymerase activity, wherein said polypeptide is selected from the group consisting of SEQ ID NO:
- 17, SEQ ID NO:
- 18, and SEQ ID NO:
- 19.
An isolated and purified polypeptide comprising the polymerase domain of the C-terminus of the NS5 polypeptide of a flavivirus, wherein said polypeptide has having polymerase activity and wherein the full-length amino acid sequence of said polypeptide has at least 80% of identity with the SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.