Chordin-like molecules and uses thereof
AssigneeAmgen Inc.
InventorsNaoki Nakayama, Duanzhi Wen, Chun-ya Han, Ching He, Dongyin Yu
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Abstract
The present invention provides Chordin-Like, (CHL) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing CHL polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with CHL polypeptides.
Claims12
An isolated polynucleotide, selected from:
- (a) a polynucleotide comprising nucleotides 1-1341 of SEQ ID NO:11;
- (b) a polynucleotide that encodes a polypeptide comprising amino acids 1-447 of SEQ ID NO:12;
- and
- (c) a nucleotide sequence complementary to the full-length sequence of (a) or (b).
An isolated polynuoleotide, comprising nucleotides 1-1341 of SEQ ID NO:11.
An isolated polynucleotide, comprising a polynucleotide that encodes a polypeptide comprising amino acids 1-447 of SEQ ID NO:12.
An isolated polynucleotide, selected from:
- (a) a polynucleotide comprising nucleotides 1-1341 of SEQ ID NO:11;
- (b) a polynucleotide that encodes a polypeptide comprising amino acids 1-447 of SEQ ID NO:12;
- and
- (c) a nucleotide sequence complementary to the full-length sequence of (a) or (b),
- wherein the polynucleotide encodes a polypeptide having a carboxy-terminus truncation, and wherein the encoded truncated polypeptide retains the capacity to bind a bone morphogenetic protein-4.
Dependencies are inferred from the claim text.