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US 7,459,280 B2Granted
Methods for diagnosing and treating kidney cancer
AssigneePicobella, LLC
InventorsBruce Wang, Matthias Wabl
Life of this patent
Estimating the term…
Abstract
Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
Claims8
A histological method for examining human kidney tissue for the presence of kidney cancer, comprising
- staining the kidney tissue with an antibody specific against a selected domain or epitope of CELSR1 and labeled with a detectable marker, to attach the marker to the surface of tissue cells having surface bound CELSR1 protein with that epitope or domain, and
- determining, based on a reduced distribution and extent of detectable marker with respect to the distribution and extent of marker in normal kidney cells, the presence of kidney cancer in the tissue.
Dependencies are inferred from the claim text.