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US 7,459,169 B2Granted
Surface coating comprising bioactive compound
Assigneeallvivo, Inc.
InventorsBo Nilsson, Jonas Andersson, Karin Caldwell, Jennifer A. Neff, Kristina Nilsson-Ekdahl
Life of this patent
Estimating the term…
Abstract
Coatings comprising protein resistant components and therapeutic components on medical devices are disclosed. The coatings act to down-regulate complement activation. Medical devices can be coated with these coatings to prevent side effects and improve patency.
Claims12
A medical device comprising:
- a structure adapted for introduction into a patient, wherein the structure comprises a surface;
- a layer of coating adsorbed on the surface of the medical device;
- wherein the coating comprises a block copolymer further comprising at least one regulator of complement activation bound through an end group of the block copolymer;
- and
- wherein the regulator of complement activation is selected from the group consisting of factor H, factor H like protein 1 (FHL-1), factor H related proteins, C4 binding protein (C4bp), complement receptor 1 (CR1), compstatin, decay-accelerating factor (DAF), membrane cofactor protein (MCP), vaccinia virus complement control protein (VCP), small pox inhibitor of complement enzymes (SPICE), and fragments thereof such that the surface of the medical device is deactivating to the complement cascade as compared to a non-coated surface of the medical device.
2 more elements
A compound for coating a medical device comprising:
- a block copolymer having a therapeutic entity attached thereto, wherein the therapeutic entity is a regulator of complement activation or an active domain thereof and is selected from the group consisting of factor H, factor H like protein 1 (FHL-1), factor H related proteins, C4 binding protein (C4bp), complement receptor 1 (CR1), compstatin, decay-accelerating factor (DAF), membrane cofactor protein (MCP), vaccine virus complement control protein (VCP), small pox inhibitor of complement enzymes (SPICE), and fragments thereof such that said regulator on the medical device is deactivating to the complement cascade as compared to a non-coated surface of the medical device and wherein the block copolymer comprises one or more hydrophilic domains and at least one hydrophobic domain.
Dependencies are inferred from the claim text.