Infectious DNA as a vaccine against west nile and other flaviviruses
AssigneeUniversity of Kansas
InventorVladimir F. Yamshchikov
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Abstract
A vaccine for West Nile virus that protects a subject against West Nile infection comprising an a pharmaceutically acceptable carrier and a therapeutically effective dose of an infectious agent selected from the group consisting of: a live attenuated infectious (+) RNA virus designated as WN1415, a vector comprising infectious DNA encoding an infectious (+) RNA molecule encoding the West Nile virus, and the West Nile (+) RNA virus designated as WN956D117B3 (GenBank #M12294).
Claims19
A live attenuated homogeneous viral population comprising the WN 1415 (+) RNA virus.
A vector comprising DNA encoding infectious (+) RNA molecule encoding the West Nile virus under the control of an eukaryotic promoter, wherein the West Nile virus DNA contains a single intron which is located upstream from the prM signal sequence occurring as the first stretch of hydrophobic amino acids in the WN polyprotein.
Dependencies are inferred from the claim text.