Viral vectors for gene therapy
OwnerGöran Wadell, Ya-fang Mei +3inventors
InventorsGöran Wadell, Ya-fang Mei, Anna Segerman, Johan Skog, Kristina Lindman
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Abstract
Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural origin, such as glioblastoma, neuroblastoma and medulloblastoma. The fact that adenovirus type 11 has a comparatively low prevalence in society, together with its high affinity and infectivity, makes it very suitable for use in gene therapy.
Claims15
A purified and isolated DNA sequence comprising the nucleotide sequences defined by positions 30811-31788 and 18254- 21100 in SEQ ID NO:
- 1.
An isolated and purified DNA sequence comprising the sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.